ArticleCerebral cortex (New York, N.Y. : 1991)2020
Rhesus Macaque Brain Developmental Trajectory: A Longitudinal Analysis Using Tensor-Based Structural Morphometry and Diffusion Tensor Imaging.
Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 22 citations in OpenAlex.
- Trajectories of Response Inhibition Development in Adolescence.bioRxiv : the preprint server for biology · 2026Article
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- Single-cell spatiotemporal transcriptomic and chromatin accessibility profiling in developing postnatal human and macaque prefrontal cortex.Nature neuroscience · 2026Article
- Longitudinal measures of monkey brain structure and activity through adolescence predict cognitive maturation.Nature neuroscience · 2025Article
- Humans have a longer period of cortical maturation across depth and hierarchy than macaques.PLoS biology · 2025Article
- The Development of Socially Directed Attention: A Functional Magnetic Resonance Imaging Study in Infant Monkeys.Journal of cognitive neuroscience · 2024Article
- Brain Charts for the Rhesus Macaque Lifespan.bioRxiv : the preprint server for biology · 2024Article
- Total-Body Irradiation Alters White Matter Volume and Microstructural Integrity in Rhesus Macaques.International journal of radiation oncology, biology, physics · 2024Article
- Effects of multiple anesthetic exposures on rhesus macaque brain development: a longitudinal structural MRI analysis.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Laminar pattern of adolescent development changes in working memory neuronal activity.Journal of neurophysiology · 2023Article
- Meager Milk: Lasting Consequences for Adult Daughters of Primiparous Mothers Among Rhesus Macaques (Macaca mulatta).Integrative and comparative biology · 2023Article
- Laminar pattern of adolescent development changes in working memory neuronal activity.bioRxiv : the preprint server for biology · 2023Article
- Human-to-monkey transfer learning identifies the frontal white matter as a key determinant for predicting monkey brain age.Frontiers in aging neuroscience · 2023Article
- Spatiotemporal dynamics of nonhuman primate white matter development during the first year of life.NeuroImage · 2021Article
- Structural development of cortical lobes during the first 6 months of life in infant macaques.Developmental cognitive neuroscience · 2021Article
- Normative Analysis of Individual Brain Differences Based on a Population MRI-Based Atlas of Cynomolgus Macaques.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
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7 authors at 2 institutions in 1 country.
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Abstract
The typical developmental trajectory of brain structure among nonhuman primates (NHPs) remains poorly understood. In this study, we characterized the normative trajectory of developmental change among a cohort of rhesus monkeys (n = 28), ranging in age from 2 to 22 months, using structural MRI datasets that were longitudinally acquired every 3-4 months. We hypothesized that NHP-specific transient intracranial volume decreases reported during late infancy would be part of the typical developmental process, which is driven by volumetric contraction of gray matter in primary functional areas. To this end, we performed multiscale analyses from the whole brain to voxel level, characterizing regional heterogeneity, hemispheric asymmetry, and sexual dimorphism in developmental patterns. The longitudinal trajectory of brain development was explained by three different regional volumetric growth patterns (exponentially decreasing, undulating, and linearly increasing), which resulted in developmental brain volume curves with transient brain volumetric decreases. White matter (WM) fractional anisotropy increased with age, corresponding to WM volume increases, while mean diffusivity (MD) showed biphasic patterns. The longitudinal trajectory of brain development in young rhesus monkeys follows typical maturation patterns seen in humans, but regional volumetric and MD changes are more dynamic in rhesus monkeys compared with humans, with marked decreases followed by "rebound-like" increases.
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