ArticleNature2020
Recapitulating the human segmentation clock with pluripotent stem cells.
Abstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers.
0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed
12.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
103 citing papers in PubMed, 211 citations in OpenAlex.
- A genetically encoded redox bottleneck constrains human developmental rate.bioRxiv : the preprint server for biology · 2026Article
- OscillomeR infers ultradian oscillations and targets of the Hes family.Patterns (New York, N.Y.) · 2026Article
- Self-organization of vascularized muscle from bovine embryonic stem cells.Nature communications · 2026Article
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- Temporal Transcriptional Regulation of Human Neuronal Differentiation via Forward Programming.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Modeling Somitogenesis and Axial Development In Vitro with Axioloids.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Keeping up with the neighbours: local synchronisation of cell fate decisions during development.EMBO reports · 2026Review
- Cdh2, a downstream target of Hes7, regulates somitogenesis by supporting FGF signalling.Development (Cambridge, England) · 2025Article
- Metabolic regulation of key developmental events during mammalian embryogenesis.Nature cell biology · 2025Review
- Progress in understanding the vertebrate segmentation clock.Nature reviews. Genetics · 2025Review
- Genome-wide quantitative dissection of an arthropod segmented body plan at single-cell resolution.Communications biology · 2025Article
- A Novel Subtype of Spondylocostal Dysplasia Associated With a Heterozygous Missense FLNA Variant.Orthopaedic surgery · 2025Article
- A Cartilaginous Organoid System Derived From Human Expanded Pluripotent Stem Cells (hEPSCs).Bio-protocol · 2025Article
- Recapitulation of endochondral ossification by hPSC-derived SOX9Nature communications · 2025Article
- Integrated transcriptomic analysis of human induced pluripotent stem cell-derived osteogenic differentiation reveals a regulatory role of KLF16.bioRxiv : the preprint server for biology · 2025Article
- Metabolic activities are selective modulators for individual segmentation clock processes.Nature communications · 2025Article
- Challenges of engineering a functional growth plateFrontiers in bioengineering and biotechnology · 2025Review
- Modeling of skeletal development and diseases using human pluripotent stem cells.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Review
- Protogenin facilitates trunk-to-tail HOX code transition via modulating GDF11/SMAD2 signaling in mammalian embryos.Communications biology · 2024Article
- Article
43 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
22 authors at 4 institutions in 2 countries.
Mitsuhiro Matsuda *Laboratory for Reconstitutive Developmental Biology, RIKEN Center for Biosystems Dynamics Research (RIKEN BDR), Kobe, Japan.
Yoshihiro Yamanaka *Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.
Maya UemuraDepartment of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.
Mitsujiro OsawaDepartment of Clinical Application, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.
Megumu K SaitoDepartment of Clinical Application, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.ORCID http://orcid.org/0000-0001-8813-3614
Ayako NagahashiDepartment of Clinical Application, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.
Megumi NishioDepartment of Regeneration Science and Engineering, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.
Long GuoLaboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences (RIKEN IMS), Tokyo, Japan.
Shiro IkegawaLaboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences (RIKEN IMS), Tokyo, Japan.ORCID http://orcid.org/0000-0003-0316-2147
Satoko SakuraiDepartment of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.
Shunsuke KiharaDepartment of Fundamental Cell Technology, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.
Thomas L MaurissenDepartment of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.ORCID http://orcid.org/0000-0002-9686-2400
Michiko NakamuraDepartment of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.
Tomoko MatsumotoDepartment of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.
Hiroyuki YoshitomiDepartment of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.
Makoto IkeyaDepartment of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.
Noriaki KawakamiDepartment of Orthopedics and Spine Surgery, Meijo Hospital, Nagoya, Japan.ORCID http://orcid.org/0000-0002-7780-1020
Takuya YamamotoInstitute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan.ORCID http://orcid.org/0000-0002-0022-3947
Knut WoltjenDepartment of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.ORCID http://orcid.org/0000-0003-2293-1183
Miki EbisuyaLaboratory for Reconstitutive Developmental Biology, RIKEN Center for Biosystems Dynamics Research (RIKEN BDR), Kobe, Japan. miki.ebisuya@embl.es.ORCID http://orcid.org/0000-0003-1854-7496
Junya ToguchidaDepartment of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.ORCID http://orcid.org/0000-0002-0184-9685
Cantas AlevDepartment of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan. alev.cantas.8m@kyoto-u.ac.jp.
Kyoto University · JPEuropean Molecular Biology Laboratory · ESRIKEN Center for Integrative Medical Sciences · JPMeijo Hospital · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pluripotent stem cells are increasingly used to model different aspects of embryogenesis and organ formation
Indexed as
Abnormalities, MultipleAnimalsBasic Helix-Loop-Helix ProteinsBiological ClocksEmbryonic DevelopmentGene EditingGene Expression Regulation, DevelopmentalGlycosyltransferasesHernia, DiaphragmaticHumansIntercellular Signaling Peptides and ProteinsIntracellular Signaling Peptides and ProteinsIn Vitro TechniquesMaleMembrane ProteinsMiceBasic Helix-Loop-Helix ProteinsDKK1 protein, humanDLL3 protein, humanGlycosyltransferasesHES7 protein, humanIntercellular Signaling Peptides and ProteinsIntracellular Signaling Peptides and ProteinsLFNG protein, humanMembrane ProteinsMESP2 protein, human
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.