ArticleNature2020
Metabolites released from apoptotic cells act as tissue messengers.
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Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 302 papers.
0numbers the graph read from it
0cells of the map it votes in
302citing papers in PubMed
22.0field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
302 citing papers in PubMed, 499 citations in OpenAlex.
- The mechanism of vascular injury caused by polystyrene microplastics: Involving ferroptosis and metabolomics.iScience · 2026Article
- Efferocytosis triggered proteomic reprogramming of macrophages reveals CD97 as a novel apoptotic receptor.Cell death and differentiation · 2026Article
- Pathophysiological mechanisms of cell death affecting graft survival in liver transplantation.World journal of transplantation · 2026Review
- Extracellular vesicles for next-gen therapeutics and drug delivery.Molecular biomedicine · 2026Review
- Metabolites with a message: impacts on epigenetics and implications for epimetabopathies.EMBO reports · 2026Review
- Plasma metabolomic signatures of migraine in 479,760 adults.iScience · 2026Article
- Methylmalonic acid as a ferroptosis-derived danger signal: activation of the PI3K-NF-κB pathway drives M1 macrophage polarization in renal ischemia-reperfusion injury.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- The signaling and regulatory functions of dying cells and cell corpses.Communications biology · 2026Review
- Extracellular Vesicle-Transferred ATP-Citrate Lyase Induces Monocyte Differentiation Toward Tumor-Associated Macrophages and Fuels Hepatocellular Carcinoma Progression.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The Epidermal Growth Factor Receptor (EGFR) as a means of neuro-immune cross-conversation.Journal of neuroinflammation · 2026Review
- Protein phosphatase 2A/Hedgehog pathway governs efferocytosis of pulmonary macrophages and participates in nanoplastics-induced mouse lung injury.Cell biology and toxicology · 2026Article
- The SHEDs-derived apoptotic bodies for inflammatory regulation in spinal cord repair.NPJ Regenerative medicine · 2026Article
- Bon appétit, your phagocyte.Cell death discovery · 2026Review
- Apoptotic metabolites synthesize and inherit uniqueBioactive materials · 2026Article
- Bacillus Calmette-Guérin ncBCG427 sRNA potentially enhances intracellular bacteria survival by inhibiting apoptosis and inflammatory responses.BMC microbiology · 2026Article
- Dying cells as architects of the stem cell niche: a conserved mechanism driving tissue regeneration and tumor therapy resistance.Cell communication and signaling : CCS · 2026Review
- Creating Cell-Based Hybrid Noodles for Sustainable and Nutrient-Balanced Diets via a Serum-Free and Animal-Free 3D Co-Differentiation System.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Using animal models to decipher the role of polyamines in the pancreas and β Cell.Amino acids · 2026Review
- Dead but not gone: the interplay between the programmed cell death process and surrounding bacteria.Infection and immunity · 2026Review
- Impaired Mitophagy-Induced Apoptosis of Gingival Fibroblasts Exacerbates Diabetic Periodontitis Via THBS-1/CD36-Dependent Macrophage Activation.Inflammation · 2026Article
242 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 4 institutions in 2 countries.
Christopher B MedinaCenter for Cell Clearance, University of Virginia, Charlottesville, VA, USA.
Parul Mehrotra *VIB/UGent Inflammation Research Centre, Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
Sanja Arandjelovic *Center for Cell Clearance, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0003-1113-1965
Justin S A Perry *Center for Cell Clearance, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0003-4063-6524
Yizhan GuoDepartment of Surgery, University of Virginia, Charlottesville, VA, USA.
Sho MoriokaCenter for Cell Clearance, University of Virginia, Charlottesville, VA, USA.
Brady BarronCenter for Cell Clearance, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0002-6938-3789
Scott F WalkCenter for Cell Clearance, University of Virginia, Charlottesville, VA, USA.
Bart GhesquièreDepartment of Oncology and VIB, KU Leuven, Leuven, Belgium.
Alexander S KrupnickDepartment of Surgery, University of Virginia, Charlottesville, VA, USA.
Ulrike LorenzDepartment of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA, USA.
Kodi S RavichandranCenter for Cell Clearance, University of Virginia, Charlottesville, VA, USA. Ravi@virginia.edu.ORCID http://orcid.org/0000-0001-9049-1410
University of Virginia · USCarter Center · USVIB-KU Leuven Center for Microbiology · BEVIB-UGent Center for Inflammation Research · BE
Funding
Role of Pannexins in Vascular Smooth Muscle CellsP01HL120840 · NHLBI · UNIVERSITY OF VIRGINIA · PI BAYLISS, DOUGLAS A., RAVICHANDRAN, KODI S · 2014 to 2023
$24.0MThe Role of Neutrophils in Regulating Lung Transplant ToleranceP01AI116501 · NIAID · WASHINGTON UNIVERSITY · PI ALEXANDER S. KRUPNICK · 2015 to 2026
$19.4MCancer Research Training Program: From Molecular Mechanisms to Therapeutic StrategiesT32CA009109 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Andrew Carl Dudley, Melanie R Rutkowski · 1985 to 2026
$13.9MTRAINING IN THE PHARMACOLOGICAL SCIENCEST32GM007055 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI LYNCH, KEVIN R. · 1985 to 2022
$7.2MMechanisms regulating apoptotic cell clearance in health and diseaseR35GM122542 · NIGMS · WASHINGTON UNIVERSITY · PI RAVICHANDRAN, KODI S · 2017 to 2021
$2.3MRegulation of tumor-associated phagocyte physiology during tumor cell clearanceR00CA237728 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI PERRY, JUSTIN S · 2019 to 2021
$747kInducible and Reversible in vivo Protein Degradation (IRIP) - attempting a new approach for modulating immune responsesR21AI135455 · NIAID · UNIVERSITY OF VIRGINIA · PI LORENZ, ULRIKE · 2018 to 2019
$444kUnderstanding T cell susceptibility to regulatory T cell-mediated suppressionR21AI139967 · NIAID · UNIVERSITY OF VIRGINIA · PI LORENZ, ULRIKE · 2019 to 2020
$435kRegulation of tumor-associated phagocyte physiology during tumor cell clearanceK99CA237728 · NCI · UNIVERSITY OF VIRGINIA · PI PERRY, JUSTIN S · 2019 to 2019
$33kNCI NIH HHS K99 CA237728NCI NIH HHS R00 CA237728NCI NIH HHS T32 CA009109NHLBI NIH HHS P01 HL120840NIAID NIH HHS P01 AI116501NIAID NIH HHS R21 AI135455NIAID NIH HHS R21 AI139967NIGMS NIH HHS R35 GM122542NIGMS NIH HHS T32 GM007055
Abstract
Caspase-dependent apoptosis accounts for approximately 90% of homeostatic cell turnover in the body
Indexed as
Cellular MicroenvironmentAnimalsApoptosisArthritisCaspasesCell LineCell ProliferationCell SurvivalConnexinsDisease Models, AnimalGraft RejectionHumansInflammationLung TransplantationLymphocytesMacrophagesCaspasesConnexinsNerve Tissue ProteinsPANX1 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.