Evidence map›Paper›PMID 32238919›Full record

ArticleBritish journal of cancer2020

Diagnostic value of

Maria Togo, Takehiko Yokobori, Kimihiro Shimizu, Tadashi Handa, Kyoichi Kaira, Takaaki Sano, Mariko Tsukagoshi, Tetsuya Higuchi, Satoshi Yokoo, Ken Shirabe and 1 more

Open access · hybridAbstract read
In one paragraph

Article in British journal of cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Comparison ofCancer science · 2025
    Article
  7. CD8JCO precision oncology · 2024
    Review
  8. Lymph nodes rather than pleural metabolic activity inTranslational lung cancer research · 2024
    Article
  9. Article
  10. Article
  11. The Role of Tumor Metabolic Reprogramming in Tumor Immunity.International journal of molecular sciences · 2023
    Review
  12. Review
  13. Immune checkpoint inhibition: a future guided by radiology.The British journal of radiology · 2023
    Review
  14. Article
  15. Review
  16. Tumor infiltrating lymphocytes and radiological picture of the tumor.Medical oncology (Northwood, London, England) · 2023
    Review
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Maria TogoDepartment of Diagnostic Pathology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan. m1620030@gunma-u.ac.jp.
Takehiko YokoboriDepartment of Innovative Cancer Immunotherapy, Gunma University, Maebashi, Gunma, Japan. bori45@gunma-u.ac.jp.
Kimihiro ShimizuDepartment of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi, Gunma, Japan.
Tadashi HandaDepartment of Diagnostic Pathology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
Kyoichi KairaDepartment of Respiratory Medicine, Comprehensive Cancer Center, International Medical Center, Saitama Medical University, Hidaka, Saitama, Japan.
Takaaki SanoDepartment of Diagnostic Pathology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
Mariko TsukagoshiDepartment of Innovative Cancer Immunotherapy, Gunma University, Maebashi, Gunma, Japan.
Tetsuya HiguchiDepartment of Diagnostic Radiology and Nuclear Medicine, Gunma University, Maebashi, Gunma, Japan.
Satoshi YokooDepartment of Oral and Maxillofacial Surgery and Plastic Surgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
Ken ShirabeDepartment of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi, Gunma, Japan.
Tetsunari OyamaDepartment of Diagnostic Pathology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
Gunma University · JPSaitama Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLately, immune checkpoint proteins, such as programmed death 1 (PD-1) and its ligand-1 (PD-L1), have garnered attention as a new target in oral squamous cell carcinoma (OSCC). Reportedly, fluoro-D-glucose (FDG)-uptake alteration by anti-PD-1 antibody treatment depicts the response in patients with lung cancer. This study aims to elucidate the correlations between tumour immune status, clinicopathological factors,

methodsWe performed immunohistochemical analysis of PD-L1, hypoxia-inducible factor 1 A (HIF-1A), glucose transporter type 1 (GLUT1), CD8, E-cadherin and Ki-67 on 59 operable OSCC samples. We assessed the correlations between these factors and preoperative

resultsLow expression of PD-L1 in OSCC correlated with cancer aggressiveness, poor prognosis, high

conclusions

Indexed as

AgedB7-H1 AntigenBiomarkers, TumorCD8-Positive T-LymphocytesDrug Resistance, NeoplasmFemaleFluorodeoxyglucose F18Head and Neck NeoplasmsHumansImmune Checkpoint InhibitorsLymphocytes, Tumor-InfiltratingMaleMiddle AgedPositron Emission Tomography Computed TomographySquamous Cell Carcinoma of Head and NeckB7-H1 AntigenBiomarkers, TumorCD274 protein, humanFluorodeoxyglucose F18Immune Checkpoint Inhibitors

Identifiers

PMID32238919
PMCPMC7250916
OpenAlexW3014410046

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.