ArticleScientific reports2020
Response to change in the number of visual stimuli in zebrafish:A behavioural and molecular study.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 56 citations in OpenAlex.
- Towards a unified biology of vertebrate number sense.Communications biology · 2026Review
- Behavioral Dynamics of Zebrafish Under Hydrodynamic Stimuli Induced by Magnetic Microactuator in Microfluidics.Biosensors · 2026Article
- Exploring the Neural Substrates of Number Sense: A Perspective on Genetics, Behaviour and Neural Circuity.The European journal of neuroscience · 2026Review
- Protocol for assessing visual stimulus discrimination in Danionella cerebrum and Danio rerio using habituation/dishabituation.STAR protocols · 2026Article
- Investigating Menzerath's law in crows and humans during cued vocal 'counting'.Animal cognition · 2026Article
- Numerical discrimination in Danionella.iScience · 2025Article
- Acoustic Tweezers for Microscopy of Living Organisms.IEEE transactions on bio-medical engineering · 2025Article
- Visual Discrimination Task in Guppies Using a Simultaneous Matching-to-Sample Procedure.Animals : an open access journal from MDPI · 2025Article
- Article
- Innate responses to numerousness reveal neural activation in different brain regions in newly-hatched visually naïve chicks.Heliyon · 2024Article
- Numerical discrimination in Drosophila melanogaster.Cell reports · 2023Article
- Brain areas activated during visual learning in the cichlid fish Pseudotropheus zebra.Brain structure & function · 2023Article
- Numerosity as a visual property: Evidence from two highly evolutionary distant species.Frontiers in physiology · 2023Article
- Use of a habituation-dishabituation test to determine canine olfactory sensitivity.Journal of the experimental analysis of behavior · 2022Article
- Translational relevance of forward genetic screens in animal models for the study of psychiatric disease.Neuroscience and biobehavioral reviews · 2022Review
- Cichlids and stingrays can add and subtract 'one' in the number space from one to five.Scientific reports · 2022Article
- Characterizing ontogeny of quantity discrimination in zebrafish.Proceedings. Biological sciences · 2022Article
- Towards a standardization of non-symbolic numerical experiments: GeNEsIS, a flexible and user-friendly tool to generate controlled stimuli.Behavior research methods · 2022Article
- Neurons in the Dorso-Central Division of Zebrafish Pallium Respond to Change in Visual Numerosity.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Archerfish number discrimination.eLife · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence has shown that a variety of vertebrates, including fish, can discriminate collections of visual items on the basis of their numerousness using an evolutionarily conserved system for approximating numerical magnitude (the so-called Approximate Number System, ANS). Here we combine a habituation/dishabituation behavioural task with molecular biology assays to start investigating the neural bases of the ANS in zebrafish. Separate groups of zebrafish underwent a habituation phase with a set of 3 or 9 small red dots, associated with a food reward. The dots changed in size, position and density from trial to trial but maintained their numerousness, and the overall areas of the stimuli was kept constant. During the subsequent dishabituation test, zebrafish faced a change (i) in number (from 3 to 9 or vice versa with the same overall surface), or (ii) in shape (with the same overall surface and number), or (iii) in size (with the same shape and number). A control group of zebrafish was shown the same stimuli as during the habituation. RT-qPCR revealed that the telencephalon and thalamus were characterized by the most consistent modulation of the expression of the immediate early genes c-fos and egr-1 upon change in numerousness; in contrast, the retina and optic tectum responded mainly to changes in stimulus size.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.