Evidence map›Paper›PMID 32238588›Full record

ArticleJournal of virology2020

Antiviral Activity and Adaptive Evolution of Avian Tetherins.

Veronika Krchlíková, Helena Fábryová, Tomáš Hron, Janet M Young, Anna Koslová, Jiří Hejnar, Klaus Strebel, Daniel Elleder

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Antiviral Effects of Avian Interferon-Stimulated Genes.Animals : an open access journal from MDPI · 2024
    Review
  5. Avian Leukosis: Will We Be Able to Get Rid of It?Animals : an open access journal from MDPI · 2023
    Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Veronika Krchlíková *Institute of Molecular Genetics, Czech Academy of Sciences, Prague, Czech Republic.
Helena Fábryová *Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA.
Tomáš HronInstitute of Molecular Genetics, Czech Academy of Sciences, Prague, Czech Republic.
Janet M YoungDivision of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Anna KoslováInstitute of Molecular Genetics, Czech Academy of Sciences, Prague, Czech Republic.
Jiří HejnarInstitute of Molecular Genetics, Czech Academy of Sciences, Prague, Czech Republic.
Klaus StrebelLaboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA kstrebel@niaid.nih.gov elleder@img.cas.cz.
Daniel EllederInstitute of Molecular Genetics, Czech Academy of Sciences, Prague, Czech Republic kstrebel@niaid.nih.gov elleder@img.cas.cz.
Czech Academy of Sciences, Institute of Molecular Genetics · CZNational Institute of Allergy and Infectious Diseases · USCzech Academy of Sciences · CZFred Hutch Cancer Center · US

Funding

X-ray Screening and Rapid Structure DeterminationP50GM082250 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KROGAN, NEVAN J · 2007 to 2018
$48.8M
Molecular Analysis Of Retroviral Genes And Their ProductsZIAAI000669 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI STREBEL, KLAUS · 2009 to 2025
$25.2M
X-ray Screening and Rapid Structure DeterminationP50AI150476 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EMERMAN, MICHAEL · 2019 to 2021
$14.4M
Molecular Analysis Of Retroviral Genes &Their ProductsZ01AI000669 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI STREBEL, KLAUS · 1993 to 2008
$852k
Intramural NIH HHS Z01 AI000669NIAID NIH HHS P50 AI150476NIGMS NIH HHS P50 GM082250
6 · The paper itself

Abstract

Tetherin/BST-2 is an antiviral protein that blocks the release of enveloped viral particles by linking them to the membrane of producing cells. At first, BST-2 genes were described only in humans and other mammals. Recent work identified BST-2 orthologs in nonmammalian vertebrates, including birds. Here, we identify the BST-2 sequence in domestic chicken (

Indexed as

Evolution, MolecularAmino Acid SequenceAnimalsAvian ProteinsAvian Sarcoma VirusesBone Marrow Stromal Antigen 2Cell LineFibroblastsgag Gene Products, Human Immunodeficiency VirusGalliformesGene Expression RegulationHEK293 CellsHIV-1Host-Pathogen InteractionsHumansPasseriformesAvian ProteinsBone Marrow Stromal Antigen 2gag Gene Products, Human Immunodeficiency Virusavian retroviruschickenrestriction factortetherin

Identifiers

PMID32238588
PMCPMC7307100
OpenAlexW3014793957

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.