Evidence map›Paper›PMID 32238579›Full record

ArticleJournal of virology2020

CD21 (Complement Receptor 2) Is the Receptor for Epstein-Barr Virus Entry into T Cells.

Nicholas A Smith, Carrie B Coleman, Benjamin E Gewurz, Rosemary Rochford

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

  1. Pooled it
  2. Review
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  5. The Significance of the Microenvironment in T/Nk-Cell Neoplasms.International journal of molecular sciences · 2025
    Review
  6. Article
  7. Article
  8. Review
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  10. The interplay of EBV virus and cell metabolism in lung cancer.Journal of cellular and molecular medicine · 2024
    Review
  11. Review
  12. Review
  13. Article
  14. Comparative Analysis of the Humoral Immune Response to the EBV Proteome across EBV-Related Malignancies.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Nicholas A SmithDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Carrie B ColemanDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Benjamin E GewurzDivision of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Rosemary RochfordDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA rosemary.rochford@ucdenver.edu.
University of Colorado Denver · USBroad Institute · US

Funding

TRAINING PROGRAM IN IMMUNOLOGYT32AI007405 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Laurel L Lenz, Raul Martin Torres · 1991 to 2026
$10.5M
Effects of Malaria on EBV Persistence in ChildrenR01CA102667 · NCI · UPSTATE MEDICAL UNIVERSITY · PI ROCHFORD, ROSEMARY · 2005 to 2014
$2.9M
Metabolic Network Remodeling in Epstein-Barr Virus LymphomagenesisR01AI137337 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI GEWURZ, BENJAMIN ELISON · 2018 to 2022
$2.2M
Developing a new model for EBV-mediated T cell diseasesR21AI122670 · NIAID · UNIVERSITY OF COLORADO DENVER · PI PELANDA, ROBERTA, ROCHFORD, ROSEMARY · 2016 to 2017
$428k
NCI NIH HHS R01 CA102667NIAID NIH HHS R01 AI137337NIAID NIH HHS R21 AI122670NIAID NIH HHS T32 AI007405
6 · The paper itself

Abstract

Epstein-Barr virus (EBV) is associated with a number of T-cell diseases, including some peripheral T-cell lymphomas, hemophagocytic lymphohistiocytosis, and chronic active EBV disease. The tropism of EBV for B cells and epithelial cell infection has been well characterized, but infection of T cells has been minimally explored. We have recently shown that the EBV type 2 (EBV-2) strain has the unique ability to infect mature T cells. Utilizing an

Indexed as

Virus InternalizationAdultB-LymphocytesEpstein-Barr Virus InfectionsFemaleGene DeletionHerpesvirus 4, HumanHumansMaleReceptors, Complement 3dT-LymphocytesReceptors, Complement 3dCD21EBVT cells

Identifiers

PMID32238579
PMCPMC7269432
OpenAlexW3014735396

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.