ArticleProceedings of the National Academy of Sciences of the United States of America2020
Connectivity and plasticity determine collagen network fracture.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 71 citations in OpenAlex.
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- Water and Collagen: A Mystery Yet to Unfold.Biomacromolecules · 2025Review
- Postmortem interval determination in excised porcine skin using a novel ultrasound-based elasticity measurement device.International journal of legal medicine · 2025Article
- FBN2 promotes the proliferation, mineralization, and differentiation of osteoblasts to accelerate fracture healing.Scientific reports · 2025Article
- Proteolysis-free amoeboid migration of melanoma cells through crowded environments via bleb-driven worrying.Developmental cell · 2024Article
- Data-driven continuum damage mechanics with built-in physics.Extreme Mechanics Letters · 2024Article
- Review
- 4-Axis 3D-Printed Tubular Biomaterials Imitating the Anisotropic Nanofiber Orientation of Porcine Aortae.Advanced healthcare materials · 2024Article
- Building block aspect ratio controls assembly, architecture, and mechanics of synthetic and natural protein networks.Nature communications · 2023Article
- Inference of long-range cell-cell force transmission from ECM remodeling fluctuations.Communications biology · 2023Article
- The non-affine fiber network solver: A multiscale fiber network material model for finite-element analysis.Journal of the mechanical behavior of biomedical materials · 2023Article
- Structural and mechanical properties of folded protein hydrogels with embedded microbubbles.Biomaterials science · 2023Article
- Cell-matrix reciprocity in 3D culture models with nonlinear elasticity.Bioactive materials · 2022Review
- Simulation of defects, flexibility and rupture in biopolymer networks.RSC advances · 2022Article
- Force Transmission in Disordered Fibre Networks.Frontiers in cell and developmental biology · 2022Article
- Cross-linking methods of type I collagen-based scaffolds for cartilage tissue engineering.American journal of translational research · 2022Review
- Biocompatible micro tweezers for 3D hydrogel organoid array mechanical characterization.PloS one · 2022Article
- Collective Cell Migration on Collagen-I Networks: The Impact of Matrix Viscoelasticity.Frontiers in cell and developmental biology · 2022Review
- Transient mechanical interactions between cells and viscoelastic extracellular matrix.Soft matter · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Collagen forms the structural scaffold of connective tissues in all mammals. Tissues are remarkably resistant against mechanical deformations because collagen molecules hierarchically self-assemble in fibrous networks that stiffen with increasing strain. Nevertheless, collagen networks do fracture when tissues are overloaded or subject to pathological conditions such as aneurysms. Prior studies of the role of collagen in tissue fracture have mainly focused on tendons, which contain highly aligned bundles of collagen. By contrast, little is known about fracture of the orientationally more disordered collagen networks present in many other tissues such as skin and cartilage. Here, we combine shear rheology of reconstituted collagen networks with computer simulations to investigate the primary determinants of fracture in disordered collagen networks. We show that the fracture strain is controlled by the coordination number of the network junctions, with less connected networks fracturing at larger strains. The hierarchical structure of collagen fine-tunes the fracture strain by providing structural plasticity at the network and fiber level. Our findings imply that low connectivity and plasticity provide protective mechanisms against network fracture that can optimize the strength of biological tissues.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.