Evidence map›Paper›PMID 32238460›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2020

Complement Deficiencies Result in Surrogate Pathways of Complement Activation in Novel Polygenic Lupus-like Models of Kidney Injury.

Sladjana Skopelja-Gardner, Lucrezia Colonna, Payton Hermanson, Xizhang Sun, Lena Tanaka, Joyce Tai, Yenly Nguyen, Jessica M Snyder, Charles E Alpers, Kelly L Hudkins and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Acute skin exposure to ultraviolet light triggers neutrophil-mediated kidney inflammation.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Sladjana Skopelja-GardnerDivision of Rheumatology, University of Washington, Seattle, WA 98109.ORCID 0000-0001-6350-9582
Lucrezia ColonnaDivision of Rheumatology, University of Washington, Seattle, WA 98109.
Payton HermansonDivision of Rheumatology, University of Washington, Seattle, WA 98109.
Xizhang SunDivision of Rheumatology, University of Washington, Seattle, WA 98109.
Lena TanakaDivision of Rheumatology, University of Washington, Seattle, WA 98109.
Joyce TaiDivision of Rheumatology, University of Washington, Seattle, WA 98109.
Yenly NguyenDivision of Rheumatology, University of Washington, Seattle, WA 98109.
Jessica M SnyderDepartment of Comparative Medicine, University of Washington, Seattle, WA 98109.
Charles E AlpersDepartment of Nephrology, University of Washington, Seattle, WA 98109.ORCID 0000-0002-1859-1772
Kelly L HudkinsDepartment of Nephrology, University of Washington, Seattle, WA 98109.
David J SalantDivision of Nephrology, Boston University, Boston, MA 02215; and.
YuFeng PengDivision of Rheumatology, University of Washington, Seattle, WA 98109; yfpeng2014@gmail.com kelkon@medicine.washington.edu.
Keith B ElkonDivision of Rheumatology, University of Washington, Seattle, WA 98109; yfpeng2014@gmail.com kelkon@medicine.washington.edu.
University of Washington · USBoston University · US

Funding

XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI Sheela Sathyanarayana · 1995 to 2026
$42.5M
RESEARCH TRAINING IN RHEUMATOLOGYT32AR007108 · NIAMS · UNIVERSITY OF WASHINGTON · PI Shaun Jackson, Tomas M Mustelin · 1986 to 2026
$6.6M
Mechanisms of end organ damage in novel polygenic lupus modelsR56AR073848 · NIAMS · UNIVERSITY OF WASHINGTON · PI ELKON, KEITH B. · 2019 to 2019
$405k
NIAMS NIH HHS R56 AR073848NIAMS NIH HHS T32 AR007108NIEHS NIH HHS P30 ES007033
6 · The paper itself

Abstract

Lupus nephritis (LN) is a major contributor to morbidity and mortality in lupus patients, but the mechanisms of kidney damage remain unclear. In this study, we introduce, to our knowledge, novel models of LN designed to resemble the polygenic nature of human lupus by embodying three key genetic alterations: the

Indexed as

AnimalsAntibodies, AntinuclearAntigens, SurfaceComplement ActivationComplement C1qComplement C3Disease Models, AnimalGlomerulonephritisHereditary Complement Deficiency DiseasesHumansKidneyLupus NephritisMannose-Binding Protein-Associated Serine ProteasesMiceMice, Inbred C57BLMice, KnockoutAntibodies, AntinuclearAntigens, SurfaceComplement C1qComplement C3Mannose-Binding Protein-Associated Serine ProteasesMASP-2 protein, mouseMfge8 protein, mouseMilk Proteins

Identifiers

PMID32238460
PMCPMC7365257
OpenAlexW3014538896

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.