ArticleDisease models & mechanisms2020
Genetic predisposition for increased red blood cell distribution width is an early risk factor for cardiovascular and renal comorbidities.
Article in Disease models & mechanisms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- Development and Validation of a Nomogram to Predict Respiratory Failure With Influenza.Immunity, inflammation and disease · 2026Article
- Epigenetic Histone β-Hydroxybutyrylation Contributes to Renoprotection by β-Hydroxybutyrate in the Dahl Rat.Hypertension (Dallas, Tex. : 1979) · 2025Article
- The link between red blood cell distribution width and 3-month prognosis in acute ischemic stroke patients: a secondary analysis of a cohort study.BMC neurology · 2025Article
- Associations between red cell distribution width and in-hospital mortality in congestive heart failure patients with chronic obstructive pulmonary disease: a retrospective cohort study.Frontiers in medicine · 2025Article
- Red cell distribution width-a potential prognostic indicator for colorectal cancer patients after radical resection in China.Journal of gastrointestinal oncology · 2023Article
- Six Decades of History of Hypertension Research at the University of Toledo: Highlighting Pioneering Contributions in Biochemistry, Genetics, and Host-Microbiota Interactions.Current hypertension reports · 2022Review
- Microbiota Introduced to Germ-Free Rats Restores Vascular Contractility and Blood Pressure.Hypertension (Dallas, Tex. : 1979) · 2020Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Red blood cell distribution width (RDW) is a measurement of the variation in size and volume of red blood cells (RBCs). Increased RDW, indicating a high heterogeneity of RBCs, is prominently associated with a variety of illnesses, especially cardiovascular diseases. However, the significance of this association to the onset and progression of cardiovascular and renal diseases is unknown. We hypothesized that a genetic predisposition for increased RDW is an early risk factor for cardiovascular and renal comorbidities. Since there is no known animal model of increased RDW, we examined a CRISPR/Cas9 gene-edited rat model (Rffl
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