ArticleCancer discovery2020
Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes.
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Article in Cancer discovery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 154 papers, 3 of them syntheses that pooled it.
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154citing papers in PubMed, 3 pooled it
20.7field-weighted citation impact, top 1% of its field
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
154 citing papers in PubMed, 3 syntheses or guidelines pooled it, 273 citations in OpenAlex.
- Primary Intracranial High Grade Congenital Glial Lesions (PIHGCL): A systematic review of case reports from 1985 to 2025.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Pooled it
- A systematic study of molecular diagnosis, treatment, and prognosis in infant-type hemispheric glioma: An individual patient data meta-analysis of 164 patients.Neuro-oncology · 2026Pooled it
- Molecular Biomarker Testing for the Diagnosis of Diffuse Gliomas.Archives of pathology & laboratory medicine · 2022Guideline
- Entrectinib in children and young adults with solid or primary CNS tumors harboring NTRK, ROS1, or ALK aberrations (STARTRK-NG).Neuro-oncology · 2022Trial
- Efficacy and safety of larotrectinib in TRK fusion-positive primary central nervous system tumors.Neuro-oncology · 2022Trial
- Three decades of anaplastic lymphoma kinase: from physiological roles to cancer and immune evasion.Cancer metastasis reviews · 2026Review
- Organoids as brain tumour models: bridging the translational gap.Disease models & mechanisms · 2026Review
- Article
- Single-cell multi-omic analyses resolve the cellular diversity of ALK/ROS1/MET/NTRK-fused gliomas in infants and older children.bioRxiv : the preprint server for biology · 2026Article
- From blunt tools to bullseyes: The impact of targeted therapy in pediatric neuro-oncology.Neuro-oncology advances · 2026Review
- TRK inhibitors in pediatric gliomas.Neuro-oncology advances · 2026Review
- Metabolic dependencies and neural progenitor dysregulation: driving forces in paediatric high-grade glioma development.Cancer metastasis reviews · 2026Review
- Novel activating SNRNP70-ALK fusion in congenital infant-type hemispheric glioma displays clinical response to lorlatinib: a case-report.NPJ precision oncology · 2026Article
- Review
- Investigation of a global mouse methylome atlas reveals subtype-specific copy number alterations in pediatric cancer models.Nature genetics · 2026Article
- Morphological and Molecular Characterization of Infant-Type Hemispheric Glioma.Neurosciences (Riyadh, Saudi Arabia) · 2026Article
- Report from the National Pediatric Cancer Foundation - infantile glioma and other non-embryonal central nervous system tumors: evolving molecular advances and current treatment landscape.Frontiers in oncology · 2026Review
- Adult Low-Grade Glioma WithCase reports in pathology · 2026Article
- Current Perspectives on Pediatric Low-Grade Gliomas: Focus on BRAF and MEK Inhibition.Brain tumor research and treatment · 2026Review
- The PLEKHA1-TACC2 fusion gene drives tumorigenesis via vascular mimicry formation in esophageal squamous-cell carcinoma.Cell death and differentiation · 2025Article
94 more citing papers are in PubMed but not listed here.
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Authors and funding
114 authors at 20 institutions in 13 countries.
Matthew Clarke *Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom.
Alan Mackay *Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom.
Britta Ismer *German Cancer Research Center (DKFZ), Heidelberg, Germany.
Jessica C PicklesUCL Great Ormond Street Institute of Child Health, London, United Kingdom.ORCID https://orcid.org/0000-0001-7888-1723
Ruth G TatevossianDepartment of Neuropathology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Scott NewmanDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Tejus A BaleDepartment of Neuropathology, Memorial Sloan-Kettering Cancer Center, New York, New York.ORCID https://orcid.org/0000-0003-3641-9287
Iris StolerCharité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Neuropathology, Berlin, Germany.ORCID https://orcid.org/0000-0003-2967-7966
Elisa IzquierdoDivision of Molecular Pathology, Institute of Cancer Research, London, United Kingdom.ORCID https://orcid.org/0000-0002-3054-5832
Sara TemelsoDivision of Molecular Pathology, Institute of Cancer Research, London, United Kingdom.
Diana M CarvalhoDivision of Molecular Pathology, Institute of Cancer Research, London, United Kingdom.
Valeria MolinariDivision of Molecular Pathology, Institute of Cancer Research, London, United Kingdom.
Anna BurfordDivision of Molecular Pathology, Institute of Cancer Research, London, United Kingdom.
Louise HowellDivision of Molecular Pathology, Institute of Cancer Research, London, United Kingdom.
Alex VirasamiUCL Great Ormond Street Institute of Child Health, London, United Kingdom.
Amy R FairchildUCL Great Ormond Street Institute of Child Health, London, United Kingdom.
Aimee AveryUCL Great Ormond Street Institute of Child Health, London, United Kingdom.
Jane ChalkerUCL Great Ormond Street Institute of Child Health, London, United Kingdom.
Mark KristiansenUCL Great Ormond Street Institute of Child Health, London, United Kingdom.
Kelly HaupfearDepartment of Neuropathology, St. Jude Children's Research Hospital, Memphis, Tennessee.
James D DaltonDepartment of Neuropathology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Wilda OrismeDepartment of Neuropathology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Ji WenDepartment of Neuropathology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Michael HubankMolecular Diagnostics, Royal Marsden Hospital NHS Trust, Sutton, United Kingdom.ORCID https://orcid.org/0000-0002-2901-0742
Kathreena M KurianBrain Tumour Research Centre, University of Bristol, Bristol, United Kingdom.ORCID https://orcid.org/0000-0003-0303-3716
Catherine RoweBrain Tumour Research Centre, University of Bristol, Bristol, United Kingdom.
Mellissa MayburyThe University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, Australia.
Stephen CrosierNewcastle Hospitals NHS Foundation Trust, Newcastle, United Kingdom.
Jeffrey KnipsteinDivision of Pediatric Hematology/Oncology/BMT, Medical College of Wisconsin, Milwaukee, Wisconsin.
Ulrich SchüllerDepartment of Neuropathology, University Hospital Hamburg-Eppendorf, and Research Institute Children's Cancer Center, Hamburg, Germany.ORCID https://orcid.org/0000-0002-8731-1121
Uwe KordesPediatric Hematology and Oncology, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
David E KramSection of Pediatric Hematology-Oncology, Wake Forest School of Medicine, Winston-Salem, North Carolina.ORCID https://orcid.org/0000-0002-1928-001X
Matija SnuderlDepartment of Neuropathology, NYU Langone Health, New York, New York.
Leslie BridgesDepartment of Neuropathology, St George's Hospital NHS Trust, London, United Kingdom.
Andrew J MartinDepartment of Neurosurgery, St George's Hospital NHS Trust, London, United Kingdom.
Lawrence J DoeyDepartment of Clinical Neuropathology, Kings College Hospital NHS Trust, London, United Kingdom.
Safa Al-SarrajDepartment of Clinical Neuropathology, Kings College Hospital NHS Trust, London, United Kingdom.
Christopher ChandlerDepartment of Neurosurgery, Kings College Hospital NHS Trust, London, United Kingdom.
Bassel ZebianDepartment of Neurosurgery, Kings College Hospital NHS Trust, London, United Kingdom.
Claire CairnsDepartment of Neurosurgery, Kings College Hospital NHS Trust, London, United Kingdom.
Rachael NatrajanThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom.ORCID https://orcid.org/0000-0002-9987-2946
Jessica K R BoultDivision of Radiotherapy and Imaging, The Institute of Cancer Research, London, United Kingdom.ORCID https://orcid.org/0000-0002-3990-9663
Simon P RobinsonDivision of Radiotherapy and Imaging, The Institute of Cancer Research, London, United Kingdom.ORCID https://orcid.org/0000-0003-4101-7274
Martin SillGerman Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID https://orcid.org/0000-0001-7616-7665
Ira J DunkelDepartment of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York.ORCID https://orcid.org/0000-0001-8091-6067
Stephen W GilheeneyDepartment of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York.
Marc K RosenblumDepartment of Neuropathology, Memorial Sloan-Kettering Cancer Center, New York, New York.
Debbie HughesMolecular Diagnostics, Royal Marsden Hospital NHS Trust, Sutton, United Kingdom.
Paula Z ProszekMolecular Diagnostics, Royal Marsden Hospital NHS Trust, Sutton, United Kingdom.
Tobey J MacdonaldAflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia.
Matthias PreusserComprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.ORCID https://orcid.org/0000-0003-3541-2315
Christine HaberlerComprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Irene SlavcDepartment of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.ORCID https://orcid.org/0000-0002-9419-6790
Roger PackerCenter for Neuroscience and Behavioural Medicine, Children's National Medical Center, Washington, DC.
Ho-Keung NgDepartment of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, China.
Shani CaspiCancer Research Center, Sheba Medical Center, Tel Aviv, Israel.
Mara PopovićFaculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Barbara Faganel KotnikDepartment of Hematology and Oncology, University Children's Hospital, Ljubljana, Slovenia.ORCID https://orcid.org/0000-0002-1769-9431
Matthew D WoodDepartment of Pathology, Oregon Health & Science University, Portland, Oregon.ORCID https://orcid.org/0000-0002-2385-8128
Lissa BairdDepartment of Neurosurgery, Oregon Health & Science University, Portland, Oregon.
Monika Ashok DavareDepartment of Pediatrics, Oregon Health & Science University, Portland, Oregon.
David A SolomonDepartment of Pathology, University of California, San Francisco, California.ORCID https://orcid.org/0000-0003-4571-7999
Thale Kristin OlsenDepartment of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden.
Petter BrandalDepartment of Oncology, Oslo University Hospital, Oslo, Norway.
Michael FarrellDepartment of Histopathology, Beaumont Hospital, Dublin, Ireland.
Jane B CryanDepartment of Histopathology, Beaumont Hospital, Dublin, Ireland.
Michael CapraPaediatric Oncology, Our Lady's Children's Hospital, Dublin, Ireland.
Michael KarremannDepartment of Pediatrics, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID https://orcid.org/0000-0002-9961-4752
Jens SchittenhelmInstitute of Pathology and Neuropathology, University Hospital Tübingen, Germany.ORCID https://orcid.org/0000-0002-9168-6209
Martin U SchuhmannDepartment of Neurosurgery, University Hospital Tübingen, Germany.ORCID https://orcid.org/0000-0001-9843-7486
Martin EbingerDepartment of Pediatric Hematology and Oncology, University Hospital Tübingen, Germany.
Winand N M DinjensDepartment of Pathology, Erasmus Medical Center, Rotterdam, the Netherlands.
Kornelius KerlDepartment of Pediatric Hematology and Oncology, University Hospital Muenster, Germany.
Simone HettmerDepartment of Pediatric Hematology and Oncology, University Hospital Freiburg, Germany.ORCID https://orcid.org/0000-0003-1709-4448
Torsten PietschInstitute of Neuropathology, DGNN Brain Tumor Reference Center, University of Bonn Medical Center, Bonn, Germany.
Felipe AndreiuoloInstitute of Neuropathology, DGNN Brain Tumor Reference Center, University of Bonn Medical Center, Bonn, Germany.
Pablo Hernáiz DrieverDepartment of Paediatric Haematology/Oncology Charité Universitätsmedizin, Berlin, Germany.
Andrey KorshunovDepartment of Neuropathology, University Hospital Heidelberg, Germany.
Lotte HiddinghGerman Cancer Research Center (DKFZ), Heidelberg, Germany.
Barbara C WorstGerman Cancer Research Center (DKFZ), Heidelberg, Germany.
Dominik SturmGerman Cancer Research Center (DKFZ), Heidelberg, Germany.
Marc ZuckermannGerman Cancer Research Center (DKFZ), Heidelberg, Germany.
Olaf WittGerman Cancer Research Center (DKFZ), Heidelberg, Germany.
Tabitha BloomBRAIN UK, University of Southampton, Southampton, United Kingdom.
Clare MitchellBRAIN UK, University of Southampton, Southampton, United Kingdom.
Evelina MieleDepartment of Onco-haematology, Cell and Gene Therapy, Bambino Gesù Children's Hospital-IRCCS, Rome, Italy.ORCID https://orcid.org/0000-0002-4747-1032
Giovanna Stefania ColafatiOncological Neuroradiology Unit, Department of Diagnostic Imaging, Bambino Gesù Children's Hospital-IRCCS, Rome, Italy.ORCID https://orcid.org/0000-0002-1142-4904
Francesca Diomedi-CamasseiDepartment of Laboratories - Pathology Unit, Bambino Gesù Children's Hospital-IRCCS, Rome, Italy.
Simon BaileyNewcastle Hospitals NHS Foundation Trust, Newcastle, United Kingdom.
Andrew S MooreThe University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, Australia.ORCID https://orcid.org/0000-0001-8062-1779
Timothy E G HassallOncology Service, Queensland Children's Hospital, Brisbane, Australia.
Stephen P LowisBrain Tumour Research Centre, University of Bristol, Bristol, United Kingdom.
Maria TsoliChildren's Cancer Institute, University of New South Wales, Sydney, Australia.
Mark J CowleyChildren's Cancer Institute, University of New South Wales, Sydney, Australia.ORCID https://orcid.org/0000-0002-9519-5714
David S ZieglerChildren's Cancer Institute, University of New South Wales, Sydney, Australia.
Matthias A KarajannisDepartment of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York.ORCID https://orcid.org/0000-0002-7151-6528
Kristian AquilinaDepartment of Neurosurgery, Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom.
Darren R HargraveDepartment of Paediatric Oncology, Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom.ORCID https://orcid.org/0000-0001-8219-9807
Fernando CarcellerDivision of Clinical Studies, The Institute of Cancer Research, London, United Kingdom.ORCID https://orcid.org/0000-0003-3094-3758
Lynley V MarshallDivision of Clinical Studies, The Institute of Cancer Research, London, United Kingdom.ORCID https://orcid.org/0000-0002-6537-2118
Andreas von DeimlingDepartment of Neuropathology, University Hospital Heidelberg, Germany.
Christof M KrammDivision of Pediatric Hematology and Oncology, University Medical Centre Göttingen, Germany.ORCID https://orcid.org/0000-0002-5017-926X
Stefan M PfisterGerman Cancer Research Center (DKFZ), Heidelberg, Germany.
Felix SahmDepartment of Paediatric Haematology/Oncology Charité Universitätsmedizin, Berlin, Germany.ORCID https://orcid.org/0000-0001-5441-1962
Suzanne J BakerDepartment of Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Angela MastronuzziNeuro-oncology Unit, Department of Onco-haematology, Cell and Gene Therapy, Bambino Gesù Children's Hospital-IRCCS, Rome, Italy.
Andrea CaraiOncological Neurosurgery Unit, Department of Neuroscience and Neurorehabilitation, Bambino Gesù Children's Hospital-IRCCS, Rome, Italy.
Maria VinciDepartment of Onco-haematology, Cell and Gene Therapy, Bambino Gesù Children's Hospital-IRCCS, Rome, Italy.
David CapperCharité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Neuropathology, Berlin, Germany.ORCID https://orcid.org/0000-0003-1945-497X
Sergey PopovDivision of Molecular Pathology, Institute of Cancer Research, London, United Kingdom.
David W EllisonDepartment of Neuropathology, St. Jude Children's Research Hospital, Memphis, Tennessee. chris.jones@icr.ac.uk david.jones@kitz-heidelberg.de t.jacques@ucl.ac.uk david.ellison@stjude.org.
Thomas S JacquesUCL Great Ormond Street Institute of Child Health, London, United Kingdom. chris.jones@icr.ac.uk david.jones@kitz-heidelberg.de t.jacques@ucl.ac.uk david.ellison@stjude.org.
David T W JonesGerman Cancer Research Center (DKFZ), Heidelberg, Germany. chris.jones@icr.ac.uk david.jones@kitz-heidelberg.de t.jacques@ucl.ac.uk david.ellison@stjude.org.
Chris JonesDivision of Molecular Pathology, Institute of Cancer Research, London, United Kingdom. chris.jones@icr.ac.uk david.jones@kitz-heidelberg.de t.jacques@ucl.ac.uk david.ellison@stjude.org.
German Cancer Research Center · DEInstitute of Cancer Research · GBSt. Jude Children's Research Hospital · USGreat Ormond Street Hospital · GBBambino Gesù Children's Hospital · ITKing's College - North Carolina · USMemorial Sloan Kettering Cancer Center · USRoyal Marsden NHS Foundation Trust · GBCancer Institute of New South Wales · AUOregon Health & Science University · USUniversity Children's Hospital Tübingen · DEUniversity of Bristol · GBBeaumont Hospital · IEComprehensive Cancer Center Vienna · ATGreat Ormond Street Hospital for Children NHS Foundation Trust · GBHeidelberg University · DELife & Brain (Germany) · DENewcastle upon Tyne Hospitals NHS Foundation Trust · GBSt George's Hospital · GBTranslational Research Institute · AU
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MViral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9MThe DNA Damage Response and Tumorigenesis in the BrainP01CA096832 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI BAKER, SUZANNE J. · 2003 to 2025
$38.0MCancer Research UK 23536Cancer Research UK 27725Cancer Research UK A23536Medical Research Council G0701018Medical Research Council G1100578Medical Research Council MR/N004272/1NCI NIH HHS P01 CA096832NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA021765
Abstract
Infant high-grade gliomas appear clinically distinct from their counterparts in older children, indicating that histopathologic grading may not accurately reflect the biology of these tumors. We have collected 241 cases under 4 years of age, and carried out histologic review, methylation profiling, and custom panel, genome, or exome sequencing. After excluding tumors representing other established entities or subgroups, we identified 130 cases to be part of an "intrinsic" spectrum of disease specific to the infant population. These included those with targetable MAPK alterations, and a large proportion of remaining cases harboring gene fusions targeting
Indexed as
Gene FusionGliomaHumansInfantNeoplasm GradingPrognosisTreatment Outcome
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