Evidence map›Paper›PMID 32238263›Full record

ArticleeLife2020

Identifying the immune interactions underlying HLA class I disease associations.

Bisrat J Debebe, Lies Boelen, James C Lee, IAVI Protocol C Investigators, Chloe L Thio, Jacquie Astemborski, Gregory Kirk, Salim I Khakoo, Sharyne M Donfield, James J Goedert and 1 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Genetic variants inFrontiers in endocrinology · 2025
    Article
  5. Haplotype Analysis Reveals Pleiotropic Disease Associations in the HLA Region.medRxiv : the preprint server for health sciences · 2024
    Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. COVID-19 Pandemic: Escape of Pathogenic Variants and MHC Evolution.International journal of molecular sciences · 2022
    Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 10 institutions in 5 countries.

Bisrat J DebebeDepartment of Infectious Disease, Imperial College London, London, United Kingdom.
Lies BoelenDepartment of Infectious Disease, Imperial College London, London, United Kingdom.
James C LeeCambridge Institute for Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, United Kingdom.
IAVI Protocol C InvestigatorsJohns Hopkins University, Baltimore, United States.
Chloe L ThioJohns Hopkins University, Baltimore, United States.
Jacquie AstemborskiJohns Hopkins University, Baltimore, United States.
Gregory KirkJohns Hopkins University, Baltimore, United States.
Salim I KhakooFaculty of Medicine, University of Southampton, Southampton, United Kingdom.
Sharyne M DonfieldRho, Chapel Hill, Durham, United States.
James J GoedertDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, United States.
Becca AsquithDepartment of Infectious Disease, Imperial College London, London, United Kingdom.ORCID 0000-0002-5911-3160
International AIDS Vaccine Initiative · USJohns Hopkins University · USEmory University · USImperial College London · GBKenya Medical Research Institute · KENational Cancer Institute · USRho (United States) · USUganda Virus Research Institute · UGUniversity of Alabama · USUniversity of Cambridge · GB

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
The AIDS Linked to the Intravenous Experience (ALIVE) StudyU01DA036297 · NIDA · JOHNS HOPKINS UNIVERSITY · PI Gregory D Kirk, Shruti H Mehta · 2014 to 2026
$28.9M
INCIDENCE OF HIV INFECTIONS IN A COHORT OF IV DRUG USERSR01DA012568 · NIDA · JOHNS HOPKINS UNIVERSITY · PI MEHTA, SHRUTI H · 1999 to 2017
$15.5M
HIV and Hepatitis C Pathogenesis & The Human GenomeR01DA013324 · NIDA · JOHNS HOPKINS UNIVERSITY · PI THOMAS, DAVID L · 1999 to 2018
$12.0M
Pathogenesis of HIV and HCV in Hemophilia: HGDSR01HD041224 · NICHD · CHILDREN'S HOSPITAL LOS ANGELES · PI GOMPERTS, EDWARD DAVID · 2001 to 2004
$2.8M
Patient-Oriented Research and Mentorship in HIV and Non-Communicable DiseasesK24AI118591 · NIAID · JOHNS HOPKINS UNIVERSITY · PI KIRK, GREGORY D · 2015 to 2019
$766k
Bloodwise 15012European Commission 317040European Union Seventh Framework Programme 317040Medical Research Council G1001052Medical Research Council J007439Medical Research Council MC_UU_00027/1Medical Research Council MR/J007439/1NIAID NIH HHS K24 AI118591NICHD NIH HHS R01 HD041224NIDA NIH HHS R01 DA012568NIDA NIH HHS R01 DA013324NIDA NIH HHS U01 DA036297NIH HHS DA13324NIH HHS P51 OD011132Wellcome 103865Z/14/ZWellcome 105920/Z/14/ZWellcome Trust
6 · The paper itself

Abstract

Variation in the risk and severity of many autoimmune diseases, malignancies and infections is strongly associated with polymorphisms at the HLA class I loci. These genetic associations provide a powerful opportunity for understanding the etiology of human disease. HLA class I associations are often interpreted in the light of 'protective' or 'detrimental' CD8

Indexed as

AllelesCrohn DiseaseHepatitis CHistocompatibility Antigens Class IHIV-1HIV InfectionsHTLV-I InfectionsHumansReceptors, Antigen, T-CellReceptors, KIRHistocompatibility Antigens Class IReceptors, Antigen, T-CellReceptors, KIRCD8 T cellcomputational biologydisease associationGWASHLAhumanimmunogeneticsimmunologyinflammationnatural killer cellsystems biology

Identifiers

PMID32238263
PMCPMC7253178
OpenAlexW3014295077

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.