Evidence map›Paper›PMID 32238226›Full record

ArticleMicrobial genomics2020

Distinct patterns of mutational sensitivity for

Bryan Andrews, Stanley Fields

Open access · goldAbstract readComparative Study
In one paragraph

Article in Microbial genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Coevolutionary phage training leads to greater bacterial suppression and delays the evolution of phage resistance.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  5. Diversity and Local Coadaptation ofFrontiers in microbiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Bryan AndrewsMolecular and Cellular Biology Program, University of Washington, Seattle WA, USA.
Stanley FieldsDepartment of Genome Sciences, University of Washington, Seattle WA, USA.
University of Washington · US

Funding

INTERDISCIPLINARY TRAINING IN GENOMIC SCIENCEST32HG000035 · NHGRI · UNIVERSITY OF WASHINGTON · PI Bruce Colston Trapnell · 1995 to 2026
$24.2M
TrainingP41GM103533 · NIGMS · UNIVERSITY OF WASHINGTON · PI MACCOSS, MICHAEL · 2012 to 2021
$20.7M
NHGRI NIH HHS T32 HG000035NIGMS NIH HHS P41 GM103533
6 · The paper itself

Abstract

Bacteria can evade cohabiting phages through mutations in phage receptors, but these mutations may come at a cost if they disrupt the receptor's native cellular function. To investigate the relationship between these two conflicting activities, we generated sequence-function maps of

Indexed as

Mutation, MissenseBacterial Outer Membrane ProteinsBacteriophage lambdaEscherichia coliModels, MolecularPhenotypePolysaccharidesPorinsProtein ConformationProtein StabilityReceptors, VirusSequence Analysis, DNABacterial Outer Membrane ProteinsmaltodextrinmaltoporinsPolysaccharidesPorinsReceptors, VirusEscherichia colievolutionLamBnutrient transportphage λ

Identifiers

PMID32238226
PMCPMC7276705
OpenAlexW3015111634

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.