Evidence map›Paper›PMID 32238192›Full record

ArticleJournal of neuroinflammation2020

Vitamin B

Karina Barbosa de Queiroz, Vanessa Cavalcante-Silva, Flávia Lombardi Lopes, Gifone Aguiar Rocha, Vânia D'Almeida, Roney Santos Coimbra

Open access · goldAbstract read
In one paragraph

Article in Journal of neuroinflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Article
  3. Role of Vitamin B₆ in Testosterone Synthesis.The world journal of men's health · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Emerging Roles of Vitamin BInternational journal of molecular sciences · 2024
    Review
  10. Review
  11. Micronutrient regulation of the DNA methylome.Frontiers in epigenetics and epigenomics · 2024
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Bacterial meningitis or cobalamin deficiency: A diagnostic conundrum.Journal of family medicine and primary care · 2022
    Article
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Karina Barbosa de QueirozNeurogenômica/Imunopatologia, Instituto René Rachou (IRR), Fundação Oswaldo Cruz (FIOCRUZ), Av. Augusto de Lima, 1715, Belo Horizonte, MG, CEP 30190-002, Brazil.
Vanessa Cavalcante-SilvaDepartamento de Psicobiologia, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP-EPM), Rua Botucatu, 740, São Paulo, SP, CEP 04023-062, Brazil.
Flávia Lombardi LopesFaculdade de Medicina Veterinária de Araçatuba, Universidade Estadual Paulista (UNESP), R. Clóvis Pestana, 793, Araçatuba, SP, CEP 16050-680, Brazil.
Gifone Aguiar RochaLaboratório de Pesquisa em Bacteriologia, Departamento de Propedêutica Complementar, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Av. Prof. Alfredo Balena, 190, Belo Horizonte, MG, CEP 30130-100, Brazil.
Vânia D'AlmeidaDepartamento de Psicobiologia, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP-EPM), Rua Botucatu, 740, São Paulo, SP, CEP 04023-062, Brazil.
Roney Santos CoimbraNeurogenômica/Imunopatologia, Instituto René Rachou (IRR), Fundação Oswaldo Cruz (FIOCRUZ), Av. Augusto de Lima, 1715, Belo Horizonte, MG, CEP 30190-002, Brazil. roney.coimbra@fiocruz.br.ORCID https://orcid.org/0000-0002-9204-0573
Fundação Oswaldo Cruz · BRUniversidade Federal de São Paulo · BRUniversidade Estadual Paulista (Unesp) · BRUniversidade Federal de Minas Gerais · BR

Funding

Inova Fundação Oswaldo Cruz N/A
6 · The paper itself

Abstract

backgroundBacterial meningitis (BM) causes apoptotic damage to the hippocampus and homocysteine (Hcy) accumulation to neurotoxic levels in the cerebrospinal fluid of children. The Hcy pathway controls bioavailability of methyl, and its homeostasis can be modulated by vitamin B

methodsEleven-day old rats were intracysternally infected with Streptococcus pneumoniae serotype 3, or saline, treated with B

resultsB

conclusionHcy is likely to play a central role in hippocampal damage in the infant rat model of BM, and B

Indexed as

AnimalsApoptosisDisease Models, AnimalDNA MethylationHippocampusMeningitis, PneumococcalNeuroprotective AgentsPromoter Regions, GeneticRatsRats, WistarStreptococcus pneumoniaeVitamin B 12Neuroprotective AgentsVitamin B 12DNA methylationEpigeneticsHomocysteineMeningitisNeuroprotectionVitamin B12

Identifiers

PMID32238192
PMCPMC7115084
OpenAlexW3014772732

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.