ArticleAccounts of chemical research2020
Mechanisms of Nickel-Catalyzed Coupling Reactions and Applications in Alkene Functionalization.
Article in Accounts of chemical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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83 citing papers in PubMed.
- Noninnocent Deep Eutectic Solvents Enable Selective, Sustainable Nickel-Catalyzed Cross-Electrophile Couplings to Diarylmethanes.ChemSusChem · 2026Article
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- Stereospecific Synthesis of Quaternary Stereocenters from Tertiary Benzylic Carboxylates.Organic letters · 2026Article
- Direct enantioselective C(spNature chemistry · 2026Article
- Recent Advances in Single-Electron-Transfer-Mediated Carbonylation.Chemical reviews · 2026Review
- Ni-catalyzed enantioselective synthesis of β-aminoboronates via spin-center shift and proton transfer.Science advances · 2025Article
- Microbial responses under sunlight-dark conditions accelerate sequestration and transformation of soil biogenic, redox and non-redox components, including As and Hg.Scientific reports · 2025Article
- Catalyst-controlled stereodivergent synthesis of polysubstituted alkenes.Nature communications · 2025Article
- Nickel-Catalyzed Cross-Dehydrogenative Coupling of Aldehydes and Alkenes toward Skipped Enones.Journal of the American Chemical Society · 2025Article
- Light-Promoted C(spJournal of the American Chemical Society · 2025Article
- C(spCatalysis science & technology · 2025Article
- 2-Substituted vs 2,9-Disubstituted Phenanthroline-NiInorganic chemistry · 2025Article
- Enantioconvergent Cobalt-Catalyzed Hydroalkylation for the Construction of Fluoro, Chloro, and Trifluoromethyl Stereogenic Centers.Angewandte Chemie (International ed. in English) · 2025Article
- Discovery of NiJournal of the American Chemical Society · 2025Article
- Nickel-catalyzed domino annulation coupling to construct oxindole analogues: A mechanistic and synthetic investigation.iScience · 2025Article
- Catalytic 1,2-Radical Acyloxy Migration: A Strategy to Access Novel Chemical Space and Reaction Profiles.Accounts of chemical research · 2025Article
- Iodide/Nickel Co-Catalyzed Manganese-Mediated Denitrogenative Cross-Electrophile Coupling of Benzotriazinones with Alkyl Sulfonates.Molecules (Basel, Switzerland) · 2025Article
- Nickel-embedded three-in-one pyridyl-quinoline-linked covalent organic framework photocatalysts for universal C(spNature communications · 2025Article
23 more citing papers are in PubMed but not listed here.
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Abstract
Nickel complexes exhibit distinct properties from other group 10 metals, including a small nuclear radius, high paring energy, low electronegativity, and low redox potentials. These properties enable Ni catalysts to accommodate and stabilize paramagnetic intermediates, access radical pathways, and undergo slow β-H elimination. Our research program investigates how each of these fundamental attributes impact the catalytic properties of Ni, in particular in the context of alkene functionalization.Alkenes are versatile functional groups, but stereoselective carbofunctionalization reactions of alkenes have been underdeveloped. This challenge may derive from the difficulty of controlling selectivity via traditional two-electron migratory insertion pathways. Ni catalysts could lead to different stereodetermining steps via radical mechanisms, allowing access to molecular scaffolds that are otherwise difficult to prepare. For example, an asymmetric alkene diarylation reaction developed by our group relies upon the radical properties of Ni(III) intermediates to control the enantioselectivity and give access to a library of chiral α,α,β-triarylethane molecules with biological activity.Mechanistic studies on a two-component reductive 1,2-difunctionalization reaction have shed light on the origin of the cross-electrophile selectivity, as C sp
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