ReviewMicrobial biotechnology2020
Ultrasound-mediated therapies for the treatment of biofilms in chronic wounds: a review of present knowledge.
Review in Microbial biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed.
- Ultrasound-Responsive Nanoparticles Enable Hydrophobic Antibiotic Release and Deep Penetration for Biofilm Treatment.JACS Au · 2026Article
- Magnetic Field-Driven Strategies for Biofilm Disruption: From Iron Oxide Nanoparticles to Adaptive Swarms of Magnetic Microrobots.ACS nano · 2026Review
- Non-porous silica nanoparticles as a cavitation sensitive vehicle for antibiotic delivery.Ultrasonics sonochemistry · 2025Article
- Recent Advances in Biofilm Control Technologies for the Food Industry.Antibiotics (Basel, Switzerland) · 2025Review
- Ultrasound-triggered release of vancomycin from a novel spinal device: Antibiotic release and efficacy in vivo.International journal of pharmaceutics · 2025Article
- Harnessing Ultrasonic Technologies to TreatMolecules (Basel, Switzerland) · 2025Review
- Antibacterial sonodynamic nanomedicine: mechanism, category, and applications.Biomaterials translational · 2025Review
- Ultrasonic strategies for mitigating microbial adhesion and biofilm formation on medical surfaces: a mini review.Frontiers in microbiology · 2025Review
- Magnetic Field/Ultrasound-Responsive FeNanomaterials (Basel, Switzerland) · 2024Article
- Review
- The Use of Photoactive Polymeric Nanoparticles and Nanofibers to Generate a Photodynamic-Mediated Antimicrobial Effect, with a Special Emphasis on Chronic Wounds.Pharmaceutics · 2024Review
- Understanding the intricacies of microbial biofilm formation and its endurance in chronic infections: a key to advancing biofilm-targeted therapeutic strategies.Archives of microbiology · 2024Review
- In Vitro and In Vivo Evaluation of Ultrasound-Triggered Release From Novel Spinal Device.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2023Article
- Selective Optical Imaging for Detection of Bacterial Biofilms in Tissues.Journal of imaging · 2023Article
- Cationic Microbubbles for Non-Selective Binding of Cavitation Nuclei to Bacterial Biofilms.Pharmaceutics · 2023Article
- Exploring the Potential of Ultrasound Therapy to Reduce Skin Scars: An In Vitro Study Using a Multi-Well Device Based on Printable Piezoelectric Transducers.Bioengineering (Basel, Switzerland) · 2023Article
- Biofilm and wound healing: from bench to bedside.European journal of medical research · 2023Review
- Larval Therapy and Larval Excretions/Secretions: A Potential Treatment for Biofilm in Chronic Wounds? A Systematic Review.Microorganisms · 2023Review
- Antimicrobial photodynamic therapy against oral biofilm: influencing factors, mechanisms, and combined actions with other strategies.Frontiers in microbiology · 2023Review
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial biofilms are an ever-growing concern for public health, featuring both inherited genetic resistance and a conferred innate tolerance to traditional antibiotic therapies. Consequently, there is a growing interest in novel methods of drug delivery, in order to increase the efficacy of antimicrobial agents. One such method is the use of acoustically activated microbubbles, which undergo volumetric oscillations and collapse upon exposure to an ultrasound field. This facilitates physical perturbation of the biofilm and provides the means to control drug delivery both temporally and spatially. In line with current literature in this area, this review offers a rounded argument for why ultrasound-responsive agents could be an integral part of advancing wound care. To achieve this, we will outline the development and clinical significance of biofilms in the context of chronic infections. We will then discuss current practices used in combating biofilms in chronic wounds and then critically evaluate the use of acoustically activated gas microbubbles as an emerging treatment modality. Moreover, we will introduce the novel concept of microbubbles carrying biologically active gases that may facilitate biofilm dispersal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.