Evidence map›Paper›PMID 32237208›Full record

Trial reportEarly intervention in psychiatry2021

Computer-aided learning for managing stress: A feasibility trial with clinical high risk adolescents and young adults.

Kristen A Woodberry, Cole Chokran, Kelsey A Johnson, Keith H Nuechterlein, David J Miklowitz, Stephen V Faraone, Larry J Seidman

Registry-linked trialOpen access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Early intervention in psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02531243 (A Pilot Study of Computerized Biofeedback Games With Young People Experiencing Psychotic-Spectrum Symptoms), which is not on this map. Cited by 3 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 3 pooled it
0.1field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02531243 nacompletednot on this map

A Pilot Study of Computerized Biofeedback Games With Young People Experiencing Psychotic-Spectrum Symptoms

TypeinterventionalSponsorBeth Israel Deaconess Medical CenterRan2015 to 2018Enrolled25ConditionsPsychosisArmsCALMS
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 syntheses or guidelines pooled it, 6 citations in OpenAlex.

  1. Biofeedback-based Digital Games and Well-being in Childhood: A Systematic Review.Research on child and adolescent psychopathology · 2025
    Pooled it
  2. Pooled it
  3. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Kristen A WoodberryPublic Psychiatry Division, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.ORCID 0000-0001-8282-1803
Cole ChokranPublic Psychiatry Division, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Kelsey A JohnsonPublic Psychiatry Division, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Keith H NuechterleinDepartments of Psychiatry and Psychology, University of California, Los Angeles, California, USA.
David J MiklowitzDepartments of Psychiatry and Psychology, University of California, Los Angeles, California, USA.
Stephen V FaraoneDepartments of Psychiatry and of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, New York, USA.
Larry J SeidmanPublic Psychiatry Division, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Beth Israel Deaconess Medical Center · USUniversity of California, Los Angeles · USSUNY Upstate Medical University · US

Funding

Family-Focused Therapy for Individuals at High Clinical Risk for Psychosis: A Confirmatory Efficacy TrialR01MH123575 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E, MIKLOWITZ, DAVID JAY · 2020 to 2023
$5.4M
1/2-Early Intervention for Youth at Risk for Bipolar DisorderR01MH093676 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIKLOWITZ, DAVID JAY · 2012 to 2016
$3.6M
Neurodevelopment and Psychosis in the 22q11.2 Copy Number VariantsR37MH085953 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CARRIE E BEARDEN · 2023 to 2026
$2.9M
Technology-Enhanced Family-Focused Treatment for Adolescents at High Risk for Mood DisordersR34MH117200 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AREVIAN, ARMEN C, MIKLOWITZ, DAVID JAY · 2018 to 2020
$933k
Family-Focused Therapy for Youth with Early-Onset Bipolar or Psychotic Disorders R33MH097007 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIKLOWITZ, DAVID JAY · 2014 to 2016
$853k
Innovative Intervention for Reducing Stress Reactivity and Risk for PsychosisK23MH102358 · NIMH · MAINEHEALTH · PI WOODBERRY, KRISTEN ANNE · 2014 to 2017
$722k
NIMH NIH HHS K23 MH102358NIMH NIH HHS R01 MH093676NIMH NIH HHS R01 MH123575NIMH NIH HHS R33 MH097007NIMH NIH HHS R34 MH117200NIMH NIH HHS R37 MH085953
6 · The paper itself

Abstract

aimThe peak onset of psychotic disorders occurs during adolescence and early adulthood, yet treatments for youth at clinical high risk (CHR) for psychosis are generally designed for adults. CHR youth, despite poor academic and social engagement, spend hours each day playing complicated videogames. The aim of this study was to test the feasibility of integrating biofeedback and cooperative videogame play within family therapy as a means of engaging and enhancing this population's resilience.

methodsWe conducted a feasibility trial of an innovative 12-week family therapy for CHR ages 12-30 (clinicaltrials.gov NCT02531243). We report feasibility outcomes and preliminary effect sizes for pre-post changes and youth-parent differences.

resultsOf 88 individuals referred to the centre who met age and CHR criteria, 11 (13%) youth-parent pairs met full criteria and engaged in treatment. Ten (91%) completed at least six sessions. Youth found CALMS initially credible, but parents tended to find it more credible and to be more satisfied over time. Surprisingly, parents reported a better game experience than youth. As a group, youth and parent participants reported experiencing reduced stress and perceiving each other as less critical by the end of treatment. Youth were rated as having significantly improved social, but not role or global functioning by the end of treatment.

conclusionsMultiuser videogames may have a role to play in engaging youth at risk for psychosis in therapy and reducing stress and familial risk factors. A number of key developments are needed to enhance the appeal, effectiveness and practicality of this approach.

Indexed as

Psychotic DisordersAdolescentAdultChildComputersFamily TherapyFeasibility StudiesHumansParentsYoung Adultbiofeedbackfamily therapymultiuserpsychosisstressvideogame

Identifiers

PMID32237208
PMCPMC8175018
OpenAlexW3014709189

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.