Evidence map›Paper›PMID 32237051›Full record

ArticleJournal of cellular and molecular medicine2020

SENP3 in monocytes/macrophages up-regulates tissue factor and mediates lipopolysaccharide-induced acute lung injury by enhancing JNK phosphorylation.

Xuelian Chen, Yimin Lao, Jing Yi, Jie Yang, Shuangjun He, Yi Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Xuelian ChenEmergency Department, South Campus, Renji Hospital Shanghai Jiaotong University School of Medicine, Shanghai, China.
Yimin LaoShanghai Key Laboratory of Tumor Microenvironment and Inflammation, Department of Biochemistry and Molecular Cell Biology, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jing YiShanghai Key Laboratory of Tumor Microenvironment and Inflammation, Department of Biochemistry and Molecular Cell Biology, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jie YangShanghai Key Laboratory of Tumor Microenvironment and Inflammation, Department of Biochemistry and Molecular Cell Biology, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shuangjun HeEmergency Department, South Campus, Renji Hospital Shanghai Jiaotong University School of Medicine, Shanghai, China.
Yi ChenEmergency Department, South Campus, Renji Hospital Shanghai Jiaotong University School of Medicine, Shanghai, China.ORCID 0000-0002-1970-9322
Renji Hospital · CNShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mechanisms underlying coagulation abnormalities in sepsis and septic acute lung injury remain unclear. Tissue factor (TF) initiates coagulation; its production can be regulated by reactive oxygen species (ROS); and monocytes/macrophages produce pathological TF during sepsis. The SUMO2/3 protease SENP3 is redox-sensitive, and SENP3 accumulation in lipopolysaccharide (LPS)-activated macrophages is ROS-dependent. To explore whether SENP3 contributes to LPS-activated coagulation, we used mice with Senp3 conditional knockout (cKO) in myeloid cells. In the model of LPS-induced sepsis, SENP3 cKO mice exhibited less severe acute lung injury than SENP3

Indexed as

Acute Lung InjuryAnimalsBiomarkersBiopsyCysteine EndopeptidasesDisease Models, AnimalImmunophenotypingJNK Mitogen-Activated Protein KinasesLipopolysaccharidesMacrophagesMiceMice, KnockoutMonocytesPhosphorylationProtein Kinase InhibitorsReactive Oxygen SpeciesBiomarkersCysteine EndopeptidasesJNK Mitogen-Activated Protein KinasesLipopolysaccharidesProtein Kinase InhibitorsReactive Oxygen SpeciesSenp3 protein, mouseThromboplastincoagulationmacrophagesmonocytesreactive oxygen speciesSENP3tissue factor

Identifiers

PMID32237051
PMCPMC7214145
OpenAlexW3015034704

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.