Evidence map›Paper›PMID 32236902›Full record

ArticleCellular and molecular neurobiology2021

Interaction Between Near-Infrared Radiation and Temozolomide in a Glioblastoma Multiform Cell Line: A Treatment Strategy?

Marcelo Augusto Germani Marinho, Magno da Silva Marques, Aline Portantiolo Lettnin, Ana Paula de Souza Votto, Daza de Moraes Vaz Batista Filgueira, Ana Paula Horn

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Marcelo Augusto Germani MarinhoPrograma de Pós-Graduação Em Ciências Fisiológicas, Instituto de Ciências Biológicas, Universidade Federal Do Rio Grande-FURG, Av. Itália, Km 8, Rio Grande, RS, CEP 96210-900, Brazil. marcelomarinho@furg.br.ORCID https://orcid.org/0000-0002-4861-0356
Magno da Silva MarquesPrograma de Pós-Graduação Em Ciências Fisiológicas, Instituto de Ciências Biológicas, Universidade Federal Do Rio Grande-FURG, Av. Itália, Km 8, Rio Grande, RS, CEP 96210-900, Brazil.ORCID https://orcid.org/0000-0003-2451-1270
Aline Portantiolo LettninPrograma de Pós-Graduação Em Ciências Fisiológicas, Instituto de Ciências Biológicas, Universidade Federal Do Rio Grande-FURG, Av. Itália, Km 8, Rio Grande, RS, CEP 96210-900, Brazil.ORCID https://orcid.org/0000-0002-4307-6107
Ana Paula de Souza VottoPrograma de Pós-Graduação Em Ciências Fisiológicas, Instituto de Ciências Biológicas, Universidade Federal Do Rio Grande-FURG, Av. Itália, Km 8, Rio Grande, RS, CEP 96210-900, Brazil.ORCID https://orcid.org/0000-0003-4057-8600
Daza de Moraes Vaz Batista FilgueiraPrograma de Pós-Graduação Em Ciências Fisiológicas, Instituto de Ciências Biológicas, Universidade Federal Do Rio Grande-FURG, Av. Itália, Km 8, Rio Grande, RS, CEP 96210-900, Brazil.ORCID https://orcid.org/0000-0002-9528-5584
Ana Paula HornPrograma de Pós-Graduação Em Ciências Fisiológicas, Instituto de Ciências Biológicas, Universidade Federal Do Rio Grande-FURG, Av. Itália, Km 8, Rio Grande, RS, CEP 96210-900, Brazil.ORCID https://orcid.org/0000-0002-6854-8545
Universidade Federal do Rio Grande · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico (BR) 447828/2014-2Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (BR) 001
6 · The paper itself

Abstract

Photodynamic therapy (PDT) is a potential therapeutic modality against cancer, resulting from the interaction of a photosensitizer (PS) and radiation that generates damage to tumor cells. The use of near-infrared radiation (IR-A) is relevant because presents recognized biological effects, such as antioxidant, neuroprotective and antitumor effects. Glioblastoma is the most aggressive central nervous system (CNS) neoplasm with high proliferation and tissue invasion capacity and is resistant to radio and chemotherapy. Here, we evaluated in vitro the possible interaction of temozolomide (TMZ) with IR-A in a glioblastoma cell line (C6) and in a human keratinocyte cell line (HaCat) how non-tumor cell model, in an attempt to search for a new treatment strategy. The effects of TMZ, IR-A and the interaction between TMZ and IR-A was evaluated by viability exclusion with trypan blue. To perform the interaction experiments, we have chosen 10 μM TMZ and 4.5 J/cm

Indexed as

AnimalsApoptosisATP-Binding Cassette, Sub-Family C ProteinsATP Binding Cassette Transporter, Subfamily B, Member 1Cell Line, TumorCell MovementCell SurvivalFluorescenceGlioblastomaHaCaT CellsHumansInfrared RaysMitotic IndexNecrosisRatsReactive Oxygen SpeciesATP-Binding Cassette, Sub-Family C ProteinsATP Binding Cassette Transporter, Subfamily B, Member 1multidrug resistance-associated protein 1Reactive Oxygen SpeciesTemozolomideAthermic infrared radiationGliomaLight-emitting diodeMultidrug resistance phenotypePhotodynamic therapy

Identifiers

PMID32236902
PMCPMC11448574
OpenAlexW3014804735

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.