Evidence map›Paper›PMID 32236882›Full record

ArticleHandbook of experimental pharmacology2020

Molecular Mechanism and Cannabinoid Pharmacology.

Lesley D Schurman, Dai Lu, Debra A Kendall, Allyn C Howlett, Aron H Lichtman

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Handbook of experimental pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07783295 (Evaluation of Bone Turnover Biomarkers, CB2 and TRPV1 Polymorphisms as Potential Preventive Data in Osteoporosis and Perception of Improvement in Quality of Life in Women With Chronic Pain Treated With Medicinal Cannabis), which is not on this map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
8.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07783295 phase2not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Evaluation of Bone Turnover Biomarkers, CB2 and TRPV1 Polymorphisms as Potential Preventive Data in Osteoporosis and Perception of Improvement in Quality of Life in Women With Chronic Pain Treated With Medicinal Cannabis

TypeinterventionalSponsorAssociação Pan-Americana Multidisciplinar de EndocanabinologiaRan2026 to 2027Enrolled80ConditionsChronic Pain, Fibromyalgia, Osteoporosis, Orofacial PainArmsFull-Spectrum Cannabis Extract 5:1 (CBD:THC)
3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.

  1. The Effects of Cannabinoids on Ischemic Stroke-Associated Neuroinflammation: A Systematic Review.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025
    Pooled it
  2. Article
  3. Selected Cannabinoids, Cannabimimetic Agents andPharmaceuticals (Basel, Switzerland) · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. New Cannabinoids and Chlorin-Type Metabolites from the Flowers ofPharmaceuticals (Basel, Switzerland) · 2025
    Article
  10. Review
  11. Evaluation of Small-Molecule Candidates as Modulators of M-Type KInternational journal of molecular sciences · 2025
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. The influence of drug class on reward in substance use disorders.Pharmacology, biochemistry, and behavior · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Lesley D SchurmanDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA.
Dai LuRangel College of Pharmacy, Health Science Center, Texas A&M University, Kingsville, TX, USA.
Debra A KendallDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, USA.
Allyn C HowlettDepartment of Physiology and Pharmacology and Center for Research on Substance Use and Addiction, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Aron H LichtmanDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA. aron.lichtman@vcuhealth.org.
Virginia Commonwealth University · USTexas A&M University – Kingsville · USUniversity of Connecticut · USWake Forest University · US

Funding

TROPANE EVALUATION AND GENERAL SCIENTIFIC SERVICES COREP50DA006634 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HOWLETT, ALLYN C · 1991 to 2019
$30.8M
TRAINING IN THE PHARMACOLOGY OF ABUSED DRUGST32DA007027 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI William L. Dewey · 1985 to 2026
$14.7M
Cannabinoid Receptors and Associated Proteins-RenewalR01DA042157 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ALLYN C HOWLETT, W TODD LOWTHER · 2017 to 2026
$5.4M
CB1 Allosteric Modulators: Molecular, Cellular and In Vivo PharmacologyR01DA039942 · NIDA · UNIVERSITY OF CONNECTICUT STORRS · PI KINSEY, STEVEN G., LICHTMAN, ARON H · 2016 to 2020
$2.6M
NIDA NIH HHS P50 DA006634NIDA NIH HHS R01 DA039942NIDA NIH HHS R01 DA042157NIDA NIH HHS T32 DA007027
6 · The paper itself

Abstract

Since antiquity, Cannabis has provoked enormous intrigue for its potential medicinal properties as well as for its unique pharmacological effects. The elucidation of its major cannabinoid constituents, Δ

Indexed as

CannabidiolCannabinoidsDronabinolEndocannabinoidsHumansReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2CannabidiolCannabinoidsDronabinolEndocannabinoidsReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2Allosteric modulationCannabinoidCannabis Use DisorderCB1/CB2 receptorCBDEndocannabinoidOpioid-sparing effectsPhytocannabinoidSynthetic cannabinoidTHC

Identifiers

PMID32236882
PMCPMC8637936
OpenAlexW3015140985

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.