ArticleBreast cancer research and treatment2020
Preserving fertility in young women undergoing chemotherapy for early breast cancer; the Maastricht experience.
Article in Breast cancer research and treatment, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Utilization and Fertility Preservation Outcomes in Women Undergoing Embryo Cryopreservation Before Breast Cancer Treatment: A Meta-Analysis.Clinical breast cancer · 2025Pooled it
- Live birth rate after female fertility preservation for cancer or haematopoietic stem cell transplantation: a systematic review and meta-analysis of the three main techniques; embryo, oocyte and ovarian tissue cryopreservation.Human reproduction (Oxford, England) · 2023Pooled it
- Safety of fertility preservation techniques before and after anticancer treatments in young women with breast cancer: a systematic review and meta-analysis.Human reproduction (Oxford, England) · 2022Pooled it
- Desire for future children and interest in consultation with a fertility specialist among adolescent and young adult (AYA) cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Review
- Reproductive outcomes after fertility preservation using tamoxifen or letrozole in women with breast cancer: a long-term follow-up.F&S reports · 2026Article
- Breaking the Silence: Barriers to Fertility Preservation Among Young Breast Cancer Patients in Ghana - a multicenter study.Research square · 2025Article
- Clinical outcomes over 12 years: a comparative analysis of oocyte cryopreservation from controlled ovarian stimulation and in vitro maturation retrieved from ovarian tissue.Journal of ovarian research · 2025Article
- Association Between Human Embryo Culture Conditions, Cryopreservation, and the Potential Risk of Birth Defects in Children Conceived Through Assisted Reproduction Technology.Medicina (Kaunas, Lithuania) · 2025Review
- Outcomes of female fertility preservation with cryopreservation of oocytes or embryos in the Netherlands: a population-based study.Human reproduction (Oxford, England) · 2024Observational
- Desire for pregnancy and fertility preservation in young patients with breast cancer.Breast cancer (Tokyo, Japan) · 2024Article
- Characterizing attitudes related to future child-bearing in young women diagnosed with early-stage breast cancer.Breast cancer research and treatment · 2024Article
- Unique challenges and outcomes of young women with breast cancers from a tertiary care cancer centre in India.Breast (Edinburgh, Scotland) · 2021Article
- Hot Topics on Fertility Preservation for Women and Girls-Current Research, Knowledge Gaps, and Future Possibilities.Journal of clinical medicine · 2021Review
- Counseling young women with early breast cancer on fertility preservation.Journal of assisted reproduction and genetics · 2019Article
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19 authors.
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Abstract
purposeWe assessed the uptake of fertility preservation (FP), recovery of ovarian function (OFR) after chemotherapy, live birth after breast cancer, and breast cancer outcomes in women with early-stage breast cancer.
methodsWomen aged below 41 years and referred to our center for FP counseling between 2008 and 2015 were included. Data on patient and tumor characteristics, ovarian function, cryopreservation (embryo/oocyte) and transfer, live birth, and disease-free survival were collected. Kaplan-Meier analyses were performed for time-to-event analyses including competing risk analyses, and patients with versus without FP were compared using the logrank test.
resultsOf 118 counseled women with a median age of 31 years (range 19-40), 34 (29%) chose FP. Women who chose FP had less often children, more often a male partner and more often favorable tumor characteristics. The 5-year OFR rate was 92% for the total group of counseled patients. In total, 26 women gave birth. The 5-year live birth rate was 27% for the total group of counseled patients. Only three women applied for transfer of their cryopreserved embryo(s), in two combined with preimplantation genetic diagnosis (PGD) because of BRCA1-mutation carrier ship. The 5-year disease-free survival rate was 91% versus 88%, for patients with versus without FP (P = 0.42).
conclusionsRemarkably, most women achieved OFR, probably related to the young age at diagnosis. Most pregnancies occurred spontaneously, two of three women applied for embryo transfer because of the opportunity to apply for PGD.
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