Evidence map›Paper›PMID 32236752›Full record

Trial reportEuropean journal of applied physiology2020

Caloric restriction induces anabolic resistance to resistance exercise.

Chaise Murphy, Karsten Koehler

Erratum issuedOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of applied physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 2 countries.

Chaise MurphyDepartment of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE, USA.ORCID http://orcid.org/0000-0003-0830-2866
Karsten KoehlerDepartment of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE, USA. karsten.koehler@tum.de.ORCID http://orcid.org/0000-0002-9618-2069
University of Nebraska–Lincoln · US

Funding

National Institute of Food and Agriculture NEB-36-083University of Nebraska Foundation Layman Award
6 · The paper itself

Abstract

purposeWeight loss can result in the loss of muscle mass and bone mineral density. Resistance exercise is commonly prescribed to attenuate these effects. However, the anabolic endocrine response to resistance exercise during caloric restriction has not been characterized.

methodsParticipants underwent 3-day conditions of caloric restriction (15 kcal kg FFM

resultsIn CRC and CRP, respectively, growth hormone peaked at 2.6 ± 0.4 and 2.5 ± 0.9 times the peak concentrations observed during CON. Despite this, insulin-like growth factor-1 concentrations declined 18.3 ± 3.4% in CRC and 27.2 ± 3.8% in CRP, which was greater than the 7.6 ± 3.6% decline in CON, over the subsequent 24 h. Sclerostin increased over the first 2 days of each intervention by 19.2 ± 5.6% in CRC, 21.8 ± 6.2% in CRP and 13.4 ± 5.9% in CON, but following the resistance exercise bout, these increases were attenuated and no longer significant.

conclusionDuring caloric restriction, there is considerable endocrine anabolic resistance to a single bout of resistance exercise which persists in the presence of post-exercise whey protein supplementation. Alternative strategies to restore the sensitivity of insulin-like growth factor-1 to growth hormone need to be explored.

Indexed as

Bone RemodelingCaloric RestrictionDietary SupplementsEnergy MetabolismResistance TrainingAdultCross-Over StudiesEnergy IntakeFemaleHumansInsulin-Like Growth Factor IMaleSingle-Blind MethodYoung AdultIGF1 protein, humanInsulin-Like Growth Factor IEnergy availabilityEnergy deficitGrowth hormoneSclerostinStrength trainingWeightlifting

Identifiers

PMID32236752
PMCPMC8233264
OpenAlexW3014229647

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.