ArticleClinical oral investigations2020
The relationship between molar incisor hypomineralization, dental caries, socioeconomic factors, and polymorphisms in the vitamin D receptor gene: a population-based study.
Article in Clinical oral investigations, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 5 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Prevalence of developmental defects of enamel in Brazil: a systematic review and meta-analysis.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Pooled it
- Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and meta-analysis.BMC pediatrics · 2024Pooled it
- Is there a rise of prevalence for Molar Incisor Hypomineralization? A meta-analysis of published data.BMC oral health · 2024Pooled it
- Prenatal, perinatal and postnatal events associated with hypomineralized second primary molar: a systematic review with meta-analysis.Clinical oral investigations · 2021Pooled it
- The prevalence of molar-incisor hypomineralization: a systematic review and meta-analysis.Scientific reports · 2021Pooled it
- Comparative study of articaine 4% versus lidocaine 2% in the local anesthesia of permanent mandibular first molars affected by MIH: a randomized controlled trial.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2023Trial
- Vitamin D Levels During Pregnancy and Dental Caries in Offspring.JAMA network open · 2025Article
- Association between multiple genetic polymorphisms and molar-incisor hypomineralization: a population-based study.Journal of applied oral science : revista FOB · 2025Article
- Socioeconomic factors and feeding in the first two years of life associated with molar incisor hypomineralisation.Frontiers in dental medicine · 2025Article
- The impact of vitamin D deficiency on caries, periodontitis, and oral cancer: A systematic review.The Saudi dental journal · 2024Review
- Molar incisor hypomineralization and oral health-related quality of life: a sample of 8-12-years-old children.Clinical oral investigations · 2024Article
- Dental pain report in children and genetic polymorphism (rs4818) in Catechol-O-Methyltransferase (COMT) gene: a cross- sectional study.Journal of applied oral science : revista FOB · 2024Article
- Association of defects of enamel with polymorphisms in the vitamin D receptor and parathyroid hormone genes.Brazilian dental journal · 2024Article
- Influence of Single-Nucleotide Polymorphisms on Vitamin D Receptor Expression in Periodontal Ligament Fibroblasts as a Response to Orthodontic Compression.International journal of molecular sciences · 2022Article
- Molar Incisor Hypomineralization: Awareness among Postdoctoral Dental Residents: A Cross-Sectional Study.Dentistry journal · 2022Article
- Molar-incisor hypomineralisation: an updated view for aetiology 20 years later.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2022Article
- Molar incisor hypomineralization: A review and prevalence in Japan.The Japanese dental science review · 2021Review
- Vitamin D, pregnancy and caries in children in the INMA-Asturias birth cohort.BMC pediatrics · 2021Article
- Assessment of Genetical, Pre, Peri and Post Natal Risk Factors of Deciduous Molar Hypomineralization (DMH), Hypomineralized Second Primary Molar (HSPM) and Molar Incisor Hypomineralization (MIH): A Narrative Review.Children (Basel, Switzerland) · 2021Review
- The Most Common Vitamin D Receptor Polymorphisms (Children (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesThe purpose of this cross-sectional study was to investigate whether polymorphisms in vitamin D receptor (VDR) genes increase the prevalence of dental caries, molar incisor hypomineralization (MIH), and hypomineralized primary second molars (HPSM). MATERIAL AND
methodsA representative population-based sample of 731 schoolchildren, 8 years of age, was randomly selected in Curitiba, Paraná, Brazil. MIH, HPSM, and dental caries were clinically assessed by four calibrated examiners (kappa > 0.80) using European Academy of Pediatric Dentistry (2003) criteria, the modified Developmental Defects of Enamel (DDE) index, and the Decayed, Missing, or Filled Teeth (DMFT) index by the World Health Organization (2013), respectively. The VDR rs739837 and rs2228570 polymorphisms were genotyped using real-time polymerase chain reaction. Associations were analyzed by Poisson regression with robust variance (α = 0.05).
resultsSchoolchildren with MIH presented a higher prevalence of dental caries (DMFT > 1, PR = 2.52, confidence interval = 1.60-3.97, p ≤ 0.001). No association was observed between MIH, HPSM, and dental caries, with rs739837 and rs2228570 polymorphisms. Individuals with the GT/GG genotype in rs739837 polymorphism presented a higher prevalence of MIH in molars and incisors than individuals TT (PR = 2.34, confidence interval = 1.08-5.07, p = 0.03).
conclusionChildren with MIH presented a significant higher prevalence of dental caries than children without MIH. To carry at least one G allele in rs739837 was associated to higher prevalence of MIH in molars and incisors. CLINICAL RELEVANCE: Our findings suggested that more severe cases with incisors affected by MIH could be associated with polymorphism in VDR gene.
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