ArticleArchives of endocrinology and metabolism2020
Diagnostic value of urinary luteinizing hormone levels in the monitoring of precocious puberty treatment.
Article in Archives of endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 14 citations in OpenAlex.
- First-morning urinary luteinizing hormone and bone age decomposition for diagnosis of central precocious puberty in girls: a two-step prediction model study.Frontiers in endocrinology · 2026Article
- Early-life phthalate mixture exposure and reproductive hormone levels during minipuberty.Frontiers in endocrinology · 2026Article
- Luteinizing Hormone Regulates Testosterone Production, Leydig Cell Proliferation, Differentiation, and Circadian Rhythm During Spermatogenesis.International journal of molecular sciences · 2025Review
- [Application of colloidal gold method and chemiluminescence method for detecting gonadotropins in morning urine to assess pubertal development status in children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Article
- Urinary gonadotropin assay on 24-h collections as a tool to detect early central puberty onset in girls: determination of predictive thresholds.Human reproduction (Oxford, England) · 2024Article
- Menarche and Time to Cycle Regularity Among Individuals Born Between 1950 and 2005 in the US.JAMA network open · 2024Article
- Role of luteinizing hormone urinary levels in the diagnostic and therapeutic management of female central precocious puberty.Italian journal of pediatrics · 2023Article
- Final adult height in children with central precocious puberty - a retrospective study.Frontiers in endocrinology · 2022Article
- The Use of Morning Urinary Gonadotropins and Sex Hormones in the Management of Early Puberty in Chinese Girls.The Journal of clinical endocrinology and metabolism · 2021Article
- Diagnosis and management of precocious sexual maturation: an updated review.European journal of pediatrics · 2021Review
- Single random measurement of urinary gonadotropin concentration for screening and monitoring girls with central precocious puberty.Annals of pediatric endocrinology & metabolism · 2021Article
- Challenges in monitoring GnRH analog treatment in central precocious puberty.Archives of endocrinology and metabolism · 2020Article
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Authors and funding
5 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Objective To determine whether first-voided urinary LH (FV-ULH) - level measurement can adequately assess pubertal suppression as much as standard tests can. Subjects and methods The study group included patients with central precocious puberty and rapidly progressing early puberty who received up to 3 - 4 doses of GnRHa therapy monthly and did not have adequate hormonal suppression after GnRH stimulation (90-minute LH level > 4 IU/L). Design: All of the participants underwent an LHRH test just after admission to the study. According to the stimulated peak LH levels, the patients were divided into 2 groups and followed until the end of the first year of treatment. The concordance between FV-ULH and stimulated LH levels was assessed. Results The FV-ULH levels in patients with inadequate hormonal suppression were significantly high compared to patients with adequate hormonal suppression. FV-ULH levels were very strongly correlated with stimulated LH levels (r = 0.91). Its correlation with basal LH levels was significant (r = 0.65). However, this positive correlation was modestly weakened after the first year of treatment. The cutoff value for FV-ULH of 1.01 mIU/mL had the highest sensitivity (92.3%) and specificity (100%). Conclusion FV-ULH levels, using more reliable and sensitive assay methods, can be used to monitor the adequacy of GnRHa therapy.
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