ArticlePloS one2020
Low back pain should be considered a health and research priority in Brazil: Lost productivity and healthcare costs between 2012 to 2016.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07232836 (The Role of Cytokines and Neuroplasticity Modulators in the Development of Spinal Canal Stenosis and the Identification of Biomarkers for the Biochemical Evaluation of Treatment in Patients Undergoing Endoscopic Spinal Canal Decompression), which is not on this map. Cited by 55 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Role of Cytokines and Neuroplasticity Modulators in the Development of Spinal Canal Stenosis and the Identification of Biomarkers for the Biochemical Evaluation of Treatment in Patients Undergoing Endoscopic Spinal Canal Decompression
Who cites it
55 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Impact of isolated lumbar extension strength training on reducing nonspecific low back pain, disability, and improving function: a systematic review and meta-analysis.Scientific reports · 2025Pooled it
- Prognostic factors for return to work in patients affected by chronic low back pain: a systematic review.Musculoskeletal surgery · 2024Pooled it
- The global prevalence of low back pain in pregnancy: a comprehensive systematic review and meta-analysis.BMC pregnancy and childbirth · 2023Pooled it
- Efficacy of mHealth Interventions for Improving the Pain and Disability of Individuals With Chronic Low Back Pain: Systematic Review and Meta-Analysis.JMIR mHealth and uHealth · 2023Pooled it
- Clinical and economic burden of low back pain in low- and middle-income countries: a systematic review.BMJ open · 2023Pooled it
- Global prevalence of hospital admissions for low back pain: a systematic review with meta-analysis.BMJ open · 2023Pooled it
- Exercise interventions can improve muscle strength, endurance, and electrical activity of lumbar extensors in individuals with non-specific low back pain: a systematic review with meta-analysis.Scientific reports · 2021Pooled it
- Cost-effectiveness of Pilates compared with home-based exercises for people with chronic non-specific low back pain: a trial-based economic evaluation.BMC musculoskeletal disorders · 2026Trial
- Effectiveness of Pilates compared with home-based exercises in individuals with chronic non-specific low back pain: Randomised controlled trial.Clinical rehabilitation · 2024Trial
- People in Brazil hold unhelpful beliefs about low back pain: An online survey using the back pain attitudes questionnaire.Brazilian journal of physical therapy · 2026Article
- Reducing inappropriate lumbar MRI referrals: a Danish pre- and post-intervention study.Chiropractic & manual therapies · 2026Article
- Spinal mobility and paraspinal muscle degeneration: a cross-sectional analysis from the Berlin Back Study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Trends in the burden of low back pain attributable to occupational ergonomic factors among the global population aged 15-64 years (1990-2021): a study based on the GBD database.Journal of health, population, and nutrition · 2026Article
- Article
- Low back pain, quality of life, and functional disability among drivers and nurses working in home healthcare services: a cross-sectional study.BMC nursing · 2026Article
- Prevalence of Low Back Pain in Saudi Arabia: A Systematic Review and Meta-Analysis of 124 Studies.Journal of pain research · 2026Review
- Non-specific low back pain prevalence and associated factors among Chinese people aged 60 years and older: a cross-sectional study.Frontiers in public health · 2026Article
- Acupuncture Combined with Core Stability Exercise for Pain, Function, and Postural Control Impairments in Chronic Low Back Pain: A Randomized Controlled Trial Protocol.Journal of pain research · 2026Article
- An empirical study of diagnosis-related group classification for hospitalization costs in lumbar disk herniation patients treated in Chinese medicine hospitals in China.Frontiers in public health · 2026Article
- Cost and outcome comparison between intradiscal condoliase injection and surgical treatment for lumbar disc herniation based on real-world data analysis.Scientific reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLow Back Pain (LBP) is associated with an increase in disability-adjusted life years, and increased risk of disability retirement and greater absenteeism in Brazil. Hence, evidence on healthcare and lost productivity costs due to LBP is of utmost importance to inform decision-makers.
methodsCost-of-illness study with top-down approach, and societal perspective. We extracted data from National databases, considering the period 2012-2016. Outpatient expenses included clinical, surgical, diagnosis, orthosis/prosthetics, and complementary actions. Inpatient care expenses included hospital and professional services, intensive care unit, and companion stay. For productivity losses, duration of work absence and associated information (work-related and non-work-related; value of the sickness absence benefit; age; gender; and economic activity) were analyzed. Lost productivity costs were calculated multiplying the absence from work (days) by the daily-benefit.
resultsThe societal costs amounted to US$ 2.2 billion, and productivity losses represented 79% of the costs. Total healthcare expenses were estimated to US$ 460 million. We found more than 880,000 diagnostic images. Individuals with LBP were in total 59 million days absent from work between 2012-2016. The mean lost days absent from work per person, for each year investigated was, respectively, 88; 84; 83; 87; and 100. Men were more days absent from work than women. In addition, rural workers presented greater absence from work compared to other professional activities.
conclusionHealthcare expenses and lost productivity costs due to LBP were substantial, hence, there is a need for improvement of health services and policies to deal with this increasing burden of illness. We found an extensive use of diagnostic imaging, which is rather discouraged by clinical guidelines. We assume that men were experiencing high levels of back pain disability compared with women, as they presented greater absenteeism and higher lost productivity costs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.