Evidence map›Paper›PMID 32235694›Full record

ArticleInternational journal of molecular sciences2020

Ablation of Endothelial TRPV4 Channels Alters the Dynamic Ca

Stuart J McFarland, David S Weber, Chung-Sik Choi, Mike T Lin, Mark S Taylor

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Mechanosensing by Vascular Endothelium.Annual review of physiology · 2024
    Review
  5. Mechanosensory entities and functionality of endothelial cells.Frontiers in cell and developmental biology · 2024
    Review
  6. Article
  7. Restricted Intimal CaFrontiers in physiology · 2022
    Article
  8. Review
  9. TRPV4: A Physio and Pathophysiologically Significant Ion Channel.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Stuart J McFarlandDepartment of Physiology and Cell Biology, University of South Alabama College of Medicine, Mobile, AL 36688, USA.
David S WeberDepartment of Physiology and Cell Biology, University of South Alabama College of Medicine, Mobile, AL 36688, USA.
Chung-Sik ChoiDepartment of Physiology and Cell Biology, University of South Alabama College of Medicine, Mobile, AL 36688, USA.
Mike T LinDepartment of Physiology and Cell Biology, University of South Alabama College of Medicine, Mobile, AL 36688, USA.
Mark S TaylorDepartment of Physiology and Cell Biology, University of South Alabama College of Medicine, Mobile, AL 36688, USA.
University of South Alabama · US

Funding

T-type Calcium Channels and von Willebrand Factor ReleaseP01HL066299 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI LEAVESLEY, SILAS JOSIAH · 2001 to 2022
$34.6M
Nosocomial pneumonias impair cognitive functionR01HL140182 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI Mike Lin · 2018 to 2026
$4.9M
Endothelial SK3 Channel Modulation of EDHF is Estrogen RegulatedR00HL102056 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI LIN, MIKE T · 2012 to 2014
$686k
Andor Revolution WD Confocal Imaging SystemS10OD020149 · OD · UNIVERSITY OF SOUTH ALABAMA · PI TAYLOR, MARK STEPHEN · 2015 to 2015
$395k
NHLBI NIH HHS P01 HL066299NHLBI NIH HHS R00 HL102056NHLBI NIH HHS R01 HL140182NIH HHS 2P01HL066299NIH HHS R00HL102056NIH HHS R01HL140182NIH HHS S100D020149NIH HHS S10 OD020149
6 · The paper itself

Abstract

Transient receptor potential vanilloid 4 channels (TRPV4) are pivotal regulators of vascular homeostasis. Altered TRPV4 signaling has recently been implicated in various cardiovascular diseases, including hypertension and atherosclerosis. These versatile nonselective cation channels increase endothelial Ca

Indexed as

Calcium SignalingGene DeletionAnimalsCarotid ArteriesEndothelium, VascularFemaleMaleMiceMice, KnockoutTRPV Cation ChannelsTrpv4 protein, mouseTRPV Cation Channelscalciumendotheliumtransient receptor potential channelsTRPV4

Identifiers

PMID32235694
PMCPMC7139994
OpenAlexW3010813106

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.