ArticleVaccines2020
Hepatitis B Seroprevalence in the Pediatric and Adolescent Population of Florence (Italy): An Update 27 Years after the Implementation of Universal Vaccination.
Article in Vaccines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Impact of the Hepatitis B Immunization Strategy Adopted in Italy from 1991: The Results of a Seroprevalence Study on the Adult Population of Florence, Italy.Pathogens (Basel, Switzerland) · 2025Article
- Seroprevalence Assessment of Anti-Varicella Antibodies among Adults in the Province of Florence (Italy).Vaccines · 2024Article
- Impact of the Universal Implementation of Adolescent Hepatitis B Vaccination in Spain.Vaccines · 2024Article
- Hepatitis B antibody levels after different doses of hepatitis B vaccination: a retrospective study based on hospitalized children.Epidemiology and infection · 2023Article
- Hepatitis B Virus Immunity Gap: A Six-Year Laboratory Data Review of Hepatitis B Serological Profiles in Gauteng Province, South Africa.Advances in virology · 2023Article
- The First 30 Years of the Universal Hepatitis-B Vaccination-Program in Italy: A Health Strategy with a Relevant and Favorable Economic-Profile.International journal of environmental research and public health · 2022Article
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- Trends in the Incidence of Acute Hepatitis B in the Polish Population and Their Determinants.Medicina (Kaunas, Lithuania) · 2021Article
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- Need to take special care of non-responders to hepatitis B vaccination among health-care workers, students and chronic patients.Human vaccines & immunotherapeutics · 2021Article
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Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHepatitis B still represents a health concern, although safe and effectivevaccines have been available since 1982. Italy introduced a program of universal vaccination againsthepatitis B in 1991. The aim of this study was to assess the immunity levels towards hepatitis B in asample of sera from the pediatric and adolescent population in the province of Florence, CentralItaly, twenty-seven years after the implementation of universal vaccination.
methodsA total of 165sera samples were collected from the resident population of Florence aged 1-18 years. The anti-HBsand anti-HBc enzyme-linked immunosorbent Assay (ELISA) tests were performed on all samples.The anamnestic and vaccination status data were also collected.
resultsSeroprevalence of anti-HBswas approximately 60%, with children aged 1-5 years having the highest positivity rate (81.6%),and decreasing trends in the older age groups. The zero prevalence of anti-HBc shows that thedetected protective immunity is mainly due to vaccination, and natural infection was not reportedin the studied population.
conclusionsThe seroprevalence of anti-HBs and the lack of anti-HBc inthis study highlights that immunity levels have been derived mainly from immunization. Thisconfirms how vaccination dramatically reduced circulation of the hepatitis B virus in Italy in thepediatric and adolescent population twenty-seven years after implementation of the mandatoryuniversal program.
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