Evidence map›Paper›PMID 32235581›Full record

ArticleNutrients2020

Chinese Propolis Prevents Obesity and Metabolism Syndromes Induced by a High Fat Diet and Accompanied by an Altered Gut Microbiota Structure in Mice.

Yufei Zheng, Yuqi Wu, Lingchen Tao, Xi Chen, Trevor Joseph Jones, Kai Wang, Fuliang Hu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 3 pooled it
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Pooled it
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  7. Gut Microbiota-Mediated Mechanisms of Traditional Chinese Medicine in Obesity Management.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Yufei ZhengCollege of Animal Sciences, Zhejiang University, Hangzhou 310058, China.
Yuqi WuCollege of Animal Sciences, Zhejiang University, Hangzhou 310058, China.
Lingchen TaoCollege of Animal Sciences, Zhejiang University, Hangzhou 310058, China.
Xi ChenCollege of Animal Sciences, Zhejiang University, Hangzhou 310058, China.
Trevor Joseph JonesDepartment of Radiation Oncology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94115, USA.
Kai WangInstitute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing 100093, China.
Fuliang HuCollege of Animal Sciences, Zhejiang University, Hangzhou 310058, China.
Zhejiang University · CNUniversity of California, San Francisco · USChinese Academy of Agricultural Sciences · CN

Funding

Modern Agroindustry Technology Research System CARS-44National Natural Science Foundation of China 31872431National Natural Science Foundation of China 31902222
6 · The paper itself

Abstract

The increasing incidence of obesity poses a great threat to public health worldwide. Recent reports also indicate the relevance of obesity in metabolic diseases. Chinese propolis (CP), as a well-studied natural nutraceutical, has shown a beneficial effect on alleviating diabetes mellitus. However, few studies have investigated the effect of CP on weight management and energy balance. We examined the beneficial effects of dietary CP on weight in high-fat diet-fed female and male mice and determined whether CP alters gut microbiota. In this study, dietary CP supplementation reduces body weight and improves insulin resistance in high-fat diet (HFD)-fed mice in a dose-dependent manner. CP treatment also reverses liver weight loss and triglyceride accumulation in association with hepatic steatosis. The 16S rRNA analysis of gut microbiota demonstrated that CP treatment modulates the composition in HFD-fed mice. Our study also suggests that male mice were more sensitive to CP treatment than female mice. Taken together, CP supplementation reduces weight gain and reverses gut microbiome dysbiosis induced by HFD. Further, the effects of CP treatment on metabolic biomarkers and microbiome structure differ by gender.

Indexed as

Dietary SupplementsGastrointestinal MicrobiomeAnimalsBody WeightDiet, High-FatDisease Models, AnimalDose-Response Relationship, DrugDysbiosisFemaleInsulin ResistanceLiverMaleMetabolic SyndromeMice, Inbred C57BLObesityPropolisPropolisTriglyceridesChinese propolis (CP), obesityhigh-fat dietmetabolic syndromesmicrobiome

Identifiers

PMID32235581
PMCPMC7230861
OpenAlexW3013205167

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.