Evidence map›Paper›PMID 32235536›Full record

ArticleMolecules (Basel, Switzerland)2020

Galangin, a Flavonoid from Lesser Galangal, Induced Apoptosis via p53-Dependent Pathway in Ovarian Cancer Cells.

Haizhi Huang, Allen Y Chen, Xingqian Ye, Rongfa Guan, Gary O Rankin, Yi Charlie Chen

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Flavonoids as Chemosensitizers in Leukemias.Advances in experimental medicine and biology · 2025
    Review
  9. Review
  10. Review
  11. Review
  12. Galangin Triggers Eryptosis and Hemolysis Through CaInternational journal of molecular sciences · 2024
    Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Haizhi HuangCollege of Life Sciences, China Jiliang University, Hangzhou 310018, China.
Allen Y ChenDepartment of Pharmacy Informatics, Seattle Children's Hospital, Seattle, WA 98101, USA.
Xingqian YeCollege of Biosystems Engineering and Food Science, National-Local Joint Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang University, Hangzhou 310058, China.
Rongfa GuanCollege of Food Science and Engineering, Zhejiang University of Technology, Hangzhou 310014, China.
Gary O RankinDepartment of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA.
Yi Charlie ChenCollege of Science, Technology & Mathematics, Alderson Broaddus University, Philippi, WV 26416, USA.
Alderson Broaddus University · USMarshall University · USSeattle Children's Hospital · USZhejiang University · CNZhejiang University of Technology · CN

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Laura F. Gibson · 2012 to 2026
$81.0M
WV INBRE: The Inhibitor of Growth Family Member 4 (ING4) inhibits L-Type Amino Acid Transporter 1 (LAT1) expression to suppress Breast CancerP20GM103434 · NIGMS · MARSHALL UNIVERSITY · PI Travis Salisbury · 2012 to 2026
$61.1M
NIGMS NIH HHS U54 GM104942NIH HHS P20GM103434
6 · The paper itself

Abstract

Among women worldwide, ovarian cancer is one of the most dangerous cancers. Patients undergoing platinum-based chemotherapy might get adverse side effects and develop resistance to drugs. In recent years, natural compounds have aroused growing attention in cancer treatment. Galangin inhibited the growth of two cell lines, A2780/CP70 and OVCAR-3, more strongly than the growth of a normal ovarian cell line, IOSE 364. The IC

Indexed as

Ovarian NeoplasmsApoptosisCell Line, TumorDown-RegulationFemaleFlavonoidsGene Expression Regulation, NeoplasticHumansSignal TransductionTumor Suppressor Protein p53FlavonoidsgalanginTP53 protein, humanTumor Suppressor Protein p53antioxidantsapoptosisflavonoidgalanginovarian cancerwestern blot

Identifiers

PMID32235536
PMCPMC7180956
OpenAlexW3013001854

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.