ArticleJournal of clinical medicine2020
Elevated Lactate Levels in Acute Pulmonary Embolism Are Associated with Prothrombotic Fibrin Clot Properties: Contribution of NETs Formation.
Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed, 38 citations in OpenAlex.
- Clinical and Socioeconomic Predictors of In-hospital Mortality in Acute Pulmonary Embolism: A Cross-sectional Study using the US National Inpatient Sample data.Research and practice in thrombosis and haemostasis · 2026Article
- Prognostic Value of Arterial Lactate in Predicting In-Hospital Mortality in Acute Pulmonary Embolism.Diagnostics (Basel, Switzerland) · 2026Article
- Mitochondrial IκBα fuels cancer progression through metabolic rewiring, endothelial activation, and thrombotic spread.Cell death discovery · 2026Article
- Sivelestat sodium mitigates lung injury post-acute pulmonary embolism by inhibiting NE-SPP1 neutrophil recruitment and restoring redox balance.Scientific reports · 2026Article
- Developing and validating a lactate-to-albumin ratio-enhanced score for mortality prediction in ICU patients with acute pulmonary embolism: a multi-cohort study.Frontiers in medicine · 2026Article
- Bidirectional regulatory mechanisms and therapeutic prospects of tumor hypercoagulable state and immunosuppressive tumor microenvironment.Oncology reviews · 2026Review
- Advancement in continuous lactate determination in untreated human serum: multipolymer-based amperometric biosensor coupled with a low-cost 3D-printed microfluidic cell.Mikrochimica acta · 2025Article
- Hexokinase 2-mediated histone H3K18la promotes PAI-1-dependent thrombosis in acute myeloid leukemia via tumor-endothelial crosstalk.Nature communications · 2025Article
- Evaluation of real-world use of pulmonary embolism thrombolysis: ERUPT.ERJ open research · 2025Article
- The Proteome Content of Blood Clots Observed Under Different Conditions: Successful Role in Predicting Clot Amyloid(ogenicity).Molecules (Basel, Switzerland) · 2025Review
- Lactate to albumin ratio as a prognostic marker for all-cause mortality in patients with venous thromboembolism: a retrospective cohort study.Frontiers in cardiovascular medicine · 2025Article
- Complement activation is associated with right ventricular dysfunction and the severity of pulmonary embolism: links with prothrombotic state.Journal of thoracic disease · 2024Article
- Management of Venous and Arterial Thrombosis.Journal of clinical medicine · 2024Article
- HMGB1 lactylation drives neutrophil extracellular trap formation in lactate-induced acute kidney injury.Frontiers in immunology · 2024Article
- Influence of Diameter and Cyclic Mechanical Stimulation on the Beating Frequency of Myocardial Cell-Laden Fibers.Gels (Basel, Switzerland) · 2023Article
- Metabolic alterations upon SARS-CoV-2 infection and potential therapeutic targets against coronavirus infection.Signal transduction and targeted therapy · 2023Review
- Characteristics and outcomes of cancer patients who develop pulmonary embolism: A cross-sectional study.Oncology letters · 2022Article
- Extracellular traps and the role in thrombosis.Frontiers in cardiovascular medicine · 2022Review
- Cardiovascular Dysfunction in COVID-19: Association Between Endothelial Cell Injury and Lactate.Frontiers in immunology · 2022Review
- Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundElevated plasma lactate levels correlate with high mortality rate in acute pulmonary embolism (PE) patients. We hypothesized that elevated lactate levels correlate with prothrombotic fibrin clot properties and enhanced neutrophil extracellular trap (NET) formation in acute PE.
methodsAs many as 126 normotensive acute PE patients (aged 58 ± 14 years) were enrolled. Plasma fibrin clot permeability (K
resultsLactate levels ≥2 mM were found in 70 (55.6%) patients in whom we observed 29% higher neutrophil count and 45% elevated plasma citH3 levels. Elevated lactate levels were associated with more prothrombotic fibrin properties as reflected by 11% reduced K
conclusionsOur findings suggest a new mechanism contributing to a negative impact of elevated lactate levels on prognosis in acute PE patients, in particular hypofibrinolysis, associated with enhanced NET formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.