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ArticleInternational journal of environmental research and public health2020

Alpha-1-Antitrypsin Deficiency and Bronchiectasis: A Concomitance or a Real Association?

Alessandro Sanduzzi, Emanuele Ciasullo, Ludovica Capitelli, Stefano Sanduzzi Zamparelli, Marialuisa Bocchino

Open access · goldAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Bronchiectasis in severe αERJ open research · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Alessandro SanduzziDepartment of Clinical Medicine and Surgery, Section of Respiratory Disease, University Federico II, AORN dei Colli-Monaldi Hospital, 80138 Naples, Italy.
Emanuele CiasulloDepartment of Clinical Medicine and Surgery, Section of Respiratory Disease, University Federico II, AORN dei Colli-Monaldi Hospital, 80138 Naples, Italy.
Ludovica CapitelliDepartment of Clinical Medicine and Surgery, Section of Respiratory Disease, University Federico II, AORN dei Colli-Monaldi Hospital, 80138 Naples, Italy.
Stefano Sanduzzi ZamparelliUniversity Luigi Vanvitelli, U.O.C. Clinica Pneumologica SUN, AORN dei Colli-Monaldi Hospital, 80138 Naples, Italy.
Marialuisa BocchinoDepartment of Clinical Medicine and Surgery, Section of Respiratory Disease, University Federico II, AORN dei Colli-Monaldi Hospital, 80138 Naples, Italy.
Ospedale Monaldi · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alpha-1-antitrypsin deficiency (AATd) is a hereditary disease, mainly characterized by early onset and the lower lobes' predominant emphysema. Bronchiectasis is characterized by dilatation of the bronchial wall and a clinical syndrome whose features are a cough, sputum production and frequent respiratory exacerbations. In the literature, there are many papers concerning these two clinical entities, but there is still a lot of debate about a possible association between them, in particular about the frequency of their association and causal links. The aim of this short communication is to show the literature reports about the association between AATd and bronchiectasis to establish the state of the art and possible future developments in this research field.

Indexed as

alpha 1-Antitrypsin DeficiencyBronchiectasisHumansLungPulmonary Emphysemaalpha-1-antitrypsin deficiencybronchiectasisemphysemarespiratory infections

Identifiers

PMID32235324
PMCPMC7178111
OpenAlexW3013106718

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.