Evidence map›Paper›PMID 32235318›Full record

ArticleToxins2020

A Humanized Monoclonal Antibody Cocktail to Prevent Pulmonary Ricin Intoxication.

Yinghui Rong, Michael Pauly, Adrian Guthals, Henry Pham, Dylan Ehrbar, Larry Zeitlin, Nicholas J Mantis

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. The Search for Antidotes Against Ricin.Mini reviews in medicinal chemistry · 2024
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yinghui RongDivision of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA.
Michael PaulyMapp Biopharmaceutical, Inc. 6160 Lusk Blvd, San Diego, CA 92121, USA.
Adrian GuthalsMapp Biopharmaceutical, Inc. 6160 Lusk Blvd, San Diego, CA 92121, USA.
Henry PhamMapp Biopharmaceutical, Inc. 6160 Lusk Blvd, San Diego, CA 92121, USA.
Dylan EhrbarDivision of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA.
Larry ZeitlinMapp Biopharmaceutical, Inc. 6160 Lusk Blvd, San Diego, CA 92121, USA.ORCID 0000-0002-6857-1024
Nicholas J MantisDivision of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA.ORCID 0000-0002-5083-8640

Funding

Development of a Preclinical Assay to Predict Efficacy of Ricin Toxin Subunit VaccinesR01AI125190 · NIAID · WADSWORTH CENTER · PI MANTIS, NICHOLAS J. · 2016 to 2020
$4.1M
Post-exposure immunotherapy for ricin exposureR44AI141282 · NIAID · ZABBIO, INC. · PI BRENNAN, MILES BURKE · 2018 to 2021
$1.9M
National Institute of Allergy and Infectious Diseases AI125190National Institute of Allergy and Infectious Diseases R44AI141282NIAID NIH HHS HHSN272201400021C
6 · The paper itself

Abstract

PB10 IgG

Indexed as

Administration, InhalationAnimalsAntibodies, Monoclonal, HumanizedAntibodies, NeutralizingAntidotesChlorocebus aethiopsDisease Models, AnimalDrug Therapy, CombinationFemaleLung DiseasesMice, Inbred BALB CPre-Exposure ProphylaxisRicinVero CellsAntibodies, Monoclonal, HumanizedAntibodies, NeutralizingAntidotesRicinantibodybiodefenselungprophylactictoxin

Identifiers

PMID32235318
PMCPMC7232472

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.