Evidence map›Paper›PMID 32235007›Full record

ArticleAging2020

A novel germline gain-of-function HIF2A mutation in hepatocellular carcinoma with polycythemia.

Jiong Yu, Xiaowei Shi, Chunzhang Yang, Petra Bullova, Christopher S Hong, Cody L Nesvick, Pauline Dmitriev, Karel Pacak, Zhengping Zhuang, Hongcui Cao and 1 more

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. A Somatic Mutation in HIF-2α Affects Glucose and Lipid Metabolism via CD36 and Ceramide.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Jiong YuState Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou City, China.
Xiaowei ShiState Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou City, China.
Chunzhang YangSurgical Neurology Branch, National Institute of Neurological Disorders and Stroke (NINDS), National Institute of Health (NIH), Bethesda, MD 20892, USA.
Petra BullovaDepartment of Molecular Medicine, Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovakia.
Christopher S HongSurgical Neurology Branch, National Institute of Neurological Disorders and Stroke (NINDS), National Institute of Health (NIH), Bethesda, MD 20892, USA.
Cody L NesvickSurgical Neurology Branch, National Institute of Neurological Disorders and Stroke (NINDS), National Institute of Health (NIH), Bethesda, MD 20892, USA.
Pauline DmitrievSurgical Neurology Branch, National Institute of Neurological Disorders and Stroke (NINDS), National Institute of Health (NIH), Bethesda, MD 20892, USA.
Karel PacakDepartment of Molecular Medicine, Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovakia.
Zhengping ZhuangSurgical Neurology Branch, National Institute of Neurological Disorders and Stroke (NINDS), National Institute of Health (NIH), Bethesda, MD 20892, USA.
Hongcui CaoState Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou City, China.
Lanjuan LiState Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou City, China.
National Institute of Neurological Disorders and Stroke · USZhejiang University · CNSlovak Academy of Sciences · SK

Funding

Analysis: Emotion-Based Alcohol Consumption with fMRI and Experimental ParadigmK01AA020102 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI CYDERS, MELISSA A · 2011 to 2015
$770k
NIAAA NIH HHS K01 AA020102
6 · The paper itself

Abstract

Hypoxia-inducible factors (HIFs) regulate oxygen sensing and expression of genes involved in angiogenesis and erythropoiesis. Polycythemia has been observed in patients with hepatocellular carcinoma (HCC), but the underlying molecular basis remains unknown. Liver tissues from 302 HCC patients, including 104 with polycythemia, were sequenced for

Indexed as

Gain of Function MutationGerm-Line MutationAdultBasic Helix-Loop-Helix ProteinsCarcinoma, HepatocellularDNA Mutational AnalysisEndothelial PAS Domain-Containing Protein 1HumansLiver NeoplasmsMalePolycythemiaBasic Helix-Loop-Helix ProteinsEndothelial PAS Domain-Containing Protein 1germlinehepatocellular carcinomahypoxia-inducible factorsmutationVon Hippel-Lindau

Identifiers

PMID32235007
PMCPMC7185130
OpenAlexW3014105578

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.