Evidence map›Paper›PMID 32234817›Full record

ArticlemBio2020

Epistatic Interplay between Type IV Secretion Effectors Engages the Small GTPase Rab2 in the

Erin P Smith, Alexis Cotto-Rosario, Elizabeth Borghesan, Kiara Held, Cheryl N Miller, Jean Celli

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 39 citations in OpenAlex.

  1. Virulence · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. ThemicroLife · 2025
    Review
  6. Beyond survival to domination:Frontiers in microbiology · 2025
    Review
  7. Article
  8. Article
  9. Infection and immunity · 2024
    Article
  10. Frontiers in cellular and infection microbiology · 2024
    Review
  11. TheMicroorganisms · 2023
    Article
  12. Article
  13. Article
  14. The Flagellar Transcriptional Regulator FtcR ControlsInternational journal of molecular sciences · 2022
    Article
  15. Article
  16. Article
  17. The VirB System Plays a Crucial Role inInternational journal of molecular sciences · 2021
    Review
  18. Article
  19. Article
  20. Uncovering the Hidden Credentials ofMicrobiology and molecular biology reviews : MMBR · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Erin P SmithPaul G. Allen School for Global Animal Health, Washington State University, Pullman, Washington, USA.ORCID 0000-0003-4822-476X
Alexis Cotto-RosarioPaul G. Allen School for Global Animal Health, Washington State University, Pullman, Washington, USA.
Elizabeth BorghesanPaul G. Allen School for Global Animal Health, Washington State University, Pullman, Washington, USA.
Kiara HeldPaul G. Allen School for Global Animal Health, Washington State University, Pullman, Washington, USA.
Cheryl N MillerPaul G. Allen School for Global Animal Health, Washington State University, Pullman, Washington, USA.
Jean CelliPaul G. Allen School for Global Animal Health, Washington State University, Pullman, Washington, USA jean.celli@wsu.edu.ORCID 0000-0002-6793-1788
Washington State University · US

Funding

TRAINING IN BIOTECHNOLOGY: EMPHASIS ON PROTEIN CHEMISTRYT32GM008336 · NIGMS · WASHINGTON STATE UNIVERSITY · PI CALL, DOUGLAS R. · 1989 to 2023
$8.9M
Infectious Diseases and Microbial Immunology Training ProgramT32AI007025 · NIAID · WASHINGTON STATE UNIVERSITY · PI Thomas H KAWULA, M KARIUKI NJENGA · 1985 to 2026
$7.4M
Effectors of Brucella intracellular replicationR01AI129992 · NIAID · WASHINGTON STATE UNIVERSITY · PI CELLI, JEAN A · 2017 to 2021
$2.1M
NIAID NIH HHS R01 AI129992NIAID NIH HHS T32 AI007025NIGMS NIH HHS T32 GM008336
6 · The paper itself

Abstract

Intracellular bacterial pathogens remodel cellular functions during their infectious cycle via the coordinated actions of effector molecules delivered through dedicated secretion systems. While the function of many individual effectors is known, how they interact to promote pathogenesis is rarely understood. The zoonotic bacterium

Indexed as

Epistasis, GeneticHost-Pathogen InteractionsBrucellaBrucellosisEndoplasmic ReticulumGene Expression Regulation, BacterialGolgi ApparatusMacrophagesProtein BindingProtein Transportrab2 GTP-Binding ProteinType IV Secretion Systemsrab2 GTP-Binding ProteinType IV Secretion SystemsBrucellaepistasismacrophagepathogenesisRab2type IV secretion

Identifiers

PMID32234817
PMCPMC7157780
OpenAlexW3014579466

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.