Evidence map›Paper›PMID 32234776›Full record

ArticlemSystems2020

Genetic Determinants Enabling Medium-Dependent Adaptation to Nafcillin in Methicillin-Resistant Staphylococcus aureus.

Michael J Salazar, Henrique Machado, Nicholas A Dillon, Hannah Tsunemoto, Richard Szubin, Samira Dahesh, Joseph Pogliano, George Sakoulas, Bernhard O Palsson, Victor Nizet and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSystems, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.2field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Ceftazidime retainsmSphere · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Media Matters, Examining Historical and ModernFrontiers in cellular and infection microbiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Michael J Salazar *Department of Bioengineering, University of California San Diego, La Jolla, California, USA.
Henrique Machado *Department of Bioengineering, University of California San Diego, La Jolla, California, USA.ORCID https://orcid.org/0000-0003-0286-0605
Nicholas A DillonCollaborative to Halt Antibiotic-Resistant Microbes, Department of Pediatrics, University of California San Diego, La Jolla, California, USA.
Hannah TsunemotoDepartment of Biology, University of California San Diego, La Jolla, California, USA.
Richard SzubinDepartment of Bioengineering, University of California San Diego, La Jolla, California, USA.
Samira DaheshCollaborative to Halt Antibiotic-Resistant Microbes, Department of Pediatrics, University of California San Diego, La Jolla, California, USA.
Joseph PoglianoCollaborative to Halt Antibiotic-Resistant Microbes, Department of Pediatrics, University of California San Diego, La Jolla, California, USA.
George SakoulasCollaborative to Halt Antibiotic-Resistant Microbes, Department of Pediatrics, University of California San Diego, La Jolla, California, USA.
Bernhard O PalssonDepartment of Bioengineering, University of California San Diego, La Jolla, California, USA.
Victor NizetCollaborative to Halt Antibiotic-Resistant Microbes, Department of Pediatrics, University of California San Diego, La Jolla, California, USA.ORCID https://orcid.org/0000-0003-3847-0422
Adam M FeistDepartment of Bioengineering, University of California San Diego, La Jolla, California, USA afeist@ucsd.edu.ORCID https://orcid.org/0000-0002-8630-4800
University of California San Diego · USNovo Nordisk Foundation · DK

Funding

Systems Biology Approach to Redefine Susceptibility Testing and Treatment of MDR Pathogens in the Context of Host ImmunityU01AI124316 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PALSSON, BERNHARD O · 2016 to 2020
$10.2M
NIAID NIH HHS U01 AI124316
6 · The paper itself

Abstract

Antimicrobial susceptibility testing standards driving clinical decision-making have centered around the use of cation-adjusted Mueller-Hinton broth (CA-MHB) as the medium with the notion of supporting bacterial growth, without consideration of recapitulating the

Indexed as

adaptive laboratory evolutionantibiotic resistancedrug resistance mechanismsnafcillinStaphylococcus aureusUSA300

Identifiers

PMID32234776
PMCPMC7112963
OpenAlexW3014536507

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.