Evidence map›Paper›PMID 32234613›Full record

ArticleRedox biology2020

Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor.

Yuehong Wang, Junting Chen, Siwei Li, Xinying Zhang, Zuoming Guo, Jing Hu, Xiaoting Shao, Ningyang Song, Yajun Zhao, Hongzhu Li and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

  1. Pooled it
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  15. Beneficial Effects of ProbioticInternational journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Yuehong WangDepartment of Pathophysiology, Harbin Medical University, Harbin, 150081, China.
Junting ChenDepartment of Anesthesiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, 150000, China.
Siwei LiDepartment of Pathophysiology, Harbin Medical University, Harbin, 150081, China.
Xinying ZhangDepartment of Pathophysiology, Harbin Medical University, Harbin, 150081, China.
Zuoming GuoDepartment of Hepatobiliary and Pancreatic Surgery, Harbin Medical University Cancer Hospital, Harbin, 150081, China.
Jing HuDepartment of Pathophysiology, Harbin Medical University, Harbin, 150081, China.
Xiaoting ShaoDepartment of Pathophysiology, Harbin Medical University, Harbin, 150081, China.
Ningyang SongDepartment of Pathophysiology, Harbin Medical University, Harbin, 150081, China.
Yajun ZhaoDepartment of Pathophysiology, Harbin Medical University, Harbin, 150081, China.
Hongzhu LiDepartment of Pathophysiology, Harbin Medical University, Harbin, 150081, China.
Guangdong YangDepartment of Chemistry and Biochemistry, Laurentian University, Sudbury, P3E 2C6, Canada.
Changqing XuDepartment of Pathophysiology, Harbin Medical University, Harbin, 150081, China.
Can WeiDepartment of Pathophysiology, Harbin Medical University, Harbin, 150081, China. Electronic address: canwei528@163.com.
Harbin Medical University · CNLaurentian University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic cardiomyopathy (DCM) is a severe complication of type 1 diabetic (T1D) patients, manifested as combined diastolic and systolic dysfunction. DCM is associated with impaired calcium homeostasis secondary to decreased calcium-sensitive receptor (CaSR) expression. Spermine, a direct agonist of CaSR, was found deficient in cardiomyocytes of T1D rats. However, the role of spermine in DCM was unclear. Here, we examined the cardioprotective effect of exogenous spermine on DCM in streptozotocin (STZ) induced-T1D rats and high-glucose (HG)-incubated neonatal rat cardiomyocytes. Exogenous spermine significantly attenuated cardiac dysfunction in T1D rats, characterized by improved echocardiography, less fibrosis, reduced myocardial endoplasmic reticulum (ER) stress and oxidative stress, and increased expression of myocardial membrane CaSR. In cultured neonatal rat cardiomyocytes, exogenous spermine attenuated myocardial injury induced by HG treatment, demonstrated by restored cellular glucose uptake capacity, reduced expression of apoptotic markers, lowered level of oxidative stress, ER stress and unfolded protein response, and upregulated cell membrane CaSR. Mechanistically, the cardioprotective effect of spermine appeared dependent upon effective elimination of reactive oxygen species (ROS) and up-regulation of CaSR expression by suppressing the Nrf2-ROS-p53-MuRF1 axis. Taken together, these results suggest that exogenous spermine protects against DCM in vivo and in vitro, partially via suppressing ROS and p53-mediated downregulation of cell membrane CaSR.

Indexed as

Diabetes MellitusDiabetic CardiomyopathiesAnimalsApoptosisCalciumDown-RegulationRatsReactive Oxygen SpeciesSpermineTumor Suppressor Protein p53CalciumReactive Oxygen SpeciesSpermineTp53 protein, ratTumor Suppressor Protein p53Calcium sensitive receptorDiabetic cardiomyopathyER stressNrf2-ROS-p53-MuRF1 axisSpermineUnfolded protein response

Identifiers

PMID32234613
PMCPMC7113441
OpenAlexW3011406800

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.