Evidence map›Paper›PMID 32234546›Full record

ArticleJournal of biomedical informatics2020

Deep ensemble learning for Alzheimer's disease classification.

Ning An, Huitong Ding, Jiaoyun Yang, Rhoda Au, Ting F A Ang

Abstract read
In one paragraph

Article in Journal of biomedical informatics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

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  10. [A study on post-traumatic stress disorder classification based on multi-atlas multi-kernel graph convolutional network].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ning AnKey Laboratory of Knowledge Engineering with Big Data of Ministry of Education, Hefei University of Technology, Hefei, China; School of Computer Science and Information Engineering, Hefei University of Technology, Hefei, China. Electronic address: ning.g.an@acm.org.
Huitong DingKey Laboratory of Knowledge Engineering with Big Data of Ministry of Education, Hefei University of Technology, Hefei, China; School of Computer Science and Information Engineering, Hefei University of Technology, Hefei, China; School of Medicine, Boston University, Boston, USA. Electronic address: ding_huitong@163.com.
Jiaoyun YangKey Laboratory of Knowledge Engineering with Big Data of Ministry of Education, Hefei University of Technology, Hefei, China; School of Computer Science and Information Engineering, Hefei University of Technology, Hefei, China. Electronic address: jiaoyun@hfut.edu.cn.
Rhoda AuSchool of Medicine, Boston University, Boston, USA; School of Public Health, Boston University, Boston, USA. Electronic address: rhodaau@bu.edu.
Ting F A AngSchool of Medicine, Boston University, Boston, USA. Electronic address: alvinang@bu.edu.

Funding

NATIONAL ALZHEIMERS COORDINATING CENTER (NACC)U01AG016976 · NIA · UNIVERSITY OF WASHINGTON · PI KUKULL, WALTER ANTHONY · 1999 to 2020
$72.8M
THERAPEUTIC EFFECTS OF INTRA-NASAL INSULIN DETEMIRP50AG005136 · NIA · UNIVERSITY OF WASHINGTON · PI GRABOWSKI, THOMAS J. · 1985 to 2019
$57.2M
VIRUS-INDUCED BRAIN PATHOLOGYP50AG005131 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BREWER, JAMES B · 1985 to 2018
$55.4M
WASHINGTON UNIVERSITY ALZHEIMERS DISEASE RESEARCH CENTERP50AG005681 · NIA · WASHINGTON UNIVERSITY · PI FAGAN, ANNE · 1985 to 2019
$52.1M
SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI LEURGANS, SUE E. · 1991 to 2020
$49.1M
Satellite Diagnostic and Treatment Clinic CoreP50AG008702 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI DE JAGER, PHILIP L · 1989 to 2019
$46.3M
National Alzheimer's Coordinating CenterU24AG072122 · NIA · UNIVERSITY OF WASHINGTON · PI STEPHENS, KARI A · 2021 to 2025
$45.8M
TREATMENT OF DEPRESSION IN ALZHEIMER'S DISEASEP50AG005133 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAMBOH, M. ILYAS · 1985 to 2019
$43.0M
THE ROLE OF ADVANCED CAA IN ALZHEIMER'S DEMENTIAP50AG005134 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI HYMAN, BRADLEY T. · 1985 to 2018
$42.1M
VASCULAR RISK AND COGNITIVE STATUS IN A LATINO POPULATIONP50AG005142 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BRASKIE, MEREDITH NICOLE · 1985 to 2019
$41.0M
VESICULAR LOCALIZATION AND FUNCTION OF PRESENILIN 1 FRAGMENTP50AG005138 · NIA · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI GROSSMAN, HILLEL · 1985 to 2019
$37.9M
'T V ASSESSMENT - MEMORY DISORDERED PATIENTS'P50AG005146 · NIA · JOHNS HOPKINS UNIVERSITY · PI ALBERT, MARILYN S. · 1985 to 2019
$37.6M
NIA NIH HHS P30 AG008017NIA NIH HHS P30 AG008051NIA NIH HHS P30 AG010124NIA NIH HHS P30 AG010129NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG012300NIA NIH HHS P30 AG013846NIA NIH HHS P30 AG013854NIA NIH HHS P30 AG019610NIA NIH HHS P30 AG028383NIA NIH HHS P30 AG035982NIA NIH HHS P30 AG049638NIA NIH HHS P30 AG053760NIA NIH HHS P30 AG066444NIA NIH HHS P30 AG066514NIA NIH HHS P30 AG066546NIA NIH HHS P30 AG072973NIA NIH HHS P50 AG005131NIA NIH HHS P50 AG005133NIA NIH HHS P50 AG005134NIA NIH HHS P50 AG005136NIA NIH HHS P50 AG005138NIA NIH HHS P50 AG005142NIA NIH HHS P50 AG005146NIA NIH HHS P50 AG005681NIA NIH HHS P50 AG008702NIA NIH HHS P50 AG016573NIA NIH HHS P50 AG016574NIA NIH HHS P50 AG023501NIA NIH HHS P50 AG025688NIA NIH HHS P50 AG033514NIA NIH HHS P50 AG047266NIA NIH HHS P50 AG047270NIA NIH HHS P50 AG047366NIA NIH HHS R01 AG054076NIA NIH HHS U01 AG016976NIA NIH HHS U24 AG072122
6 · The paper itself

Abstract

Ensemble learning uses multiple algorithms to obtain better predictive performance than any single one of its constituent algorithms could. With the growing popularity of deep learning technologies, researchers have started to ensemble these technologies for various purposes. Few, if any, however, have used the deep learning approach as a means to ensemble Alzheimer's disease classification algorithms. This paper presents a deep ensemble learning framework that aims to harness deep learning algorithms to integrate multisource data and tap the 'wisdom of experts'. At the voting layer, two sparse autoencoders are trained for feature learning to reduce the correlation of attributes and diversify the base classifiers ultimately. At the stacking layer, a nonlinear feature-weighted method based on a deep belief network is proposed to rank the base classifiers, which may violate the conditional independence. The neural network is used as a meta classifier. At the optimizing layer, over-sampling and threshold-moving are used to cope with the cost-sensitive problem. Optimized predictions are obtained based on an ensemble of probabilistic predictions by similarity calculation. The proposed deep ensemble learning framework is used for Alzheimer's disease classification. Experiments with the clinical dataset from National Alzheimer's Coordinating Center demonstrate that the classification accuracy of our proposed framework is 4% better than six well-known ensemble approaches, including the standard stacking algorithm as well. Adequate coverage of more accurate diagnostic services can be provided by utilizing the wisdom of averaged physicians. This paper points out a new way to boost the primary care of Alzheimer's disease from the view of machine learning.

Indexed as

Alzheimer DiseaseAlgorithmsHumansMachine LearningNeural Networks, ComputerAlzheimer's diseaseClassificationDeep learningEnsemble learningStacking

Identifiers

PMID32234546
PMCPMC9760486

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.