Evidence map›Paper›PMID 32234451›Full record

ReviewClinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases2020

COVID-19, SARS and MERS: are they closely related?

N Petrosillo, G Viceconte, O Ergonul, G Ippolito, E Petersen

2 registry-linked trialsOpen access · bronzeAbstract readReview
In one paragraph

Review in Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 561 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
561citing papers in PubMed, 6 pooled it
26.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04470583 unknown statusnot on this map

Evaluation of Clinical Parameters Following COVID-19 Infection in Pregnancy (COpregVID)

TypeobservationalSponsorChelsea and Westminster NHS Foundation TrustRan2020 to 2021Enrolled116ConditionsCOVID-19, 2019 Novel Coronavirus Infection, COVID-19 Infection
NCT05293665 phase3unknown statusnot on this mapstarted 2022, after this paper: background citation

A Phase 3 Multi-Center International, Randomized, Active-Controlled Platform Trial to Compare Homologous Boost of Authorized COVID-19 Vaccines and Heterologous Boost With UB-612 Vaccine

TypeinterventionalSponsorVaxxinity, Inc.Ran2022 to 2023Enrolled944ConditionsCOVID-19 VaccinesArmsUB-612, BNT162b2 vaccine, ChAdOx1-S vaccine, Sinopharm BIBP
3 · Its place in the literature

Who cites it

561 citing papers in PubMed, 6 syntheses or guidelines pooled it, 1,138 citations in OpenAlex.

  1. Pooled it
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  5. COVID-19 pandemic: the delta variant, T-cell responses, and the efficacy of developing vaccines.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
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  11. Material-to-Application Integration: Rapid Fabrication of Field-Deployable Hydrogel-SiOAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
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  17. Marine-Derived Peptides fromMicroorganisms · 2025
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501 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 5 countries.

N PetrosilloNational Institute for Infectious Diseases 'L. Spallanzani', IRCCS, Rome, Italy. Electronic address: nicola.petrosillo@inmi.it.
G ViceconteUniversity 'Federico II', Department of Clinical Medicine and Surgery, Naples, Italy.
O ErgonulKoc University, School of Medicine, Istanbul, Turkey; ESCMID Executive Committee, Switzerland.
G IppolitoNational Institute for Infectious Diseases 'L. Spallanzani', IRCCS, Rome, Italy.
E PetersenDirectorate General for Disease Surveillance and Control, Min of Health, Muscat, Oman; ESCMID Emerging Infections Task Force, ESCMID, Basel, Switzerland; Institute for Clinical Medicine, Faculty of Health Sciences, University of Aarhus, Denmark.
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani · ITAarhus University · DKFederico II University Hospital · ITKoç University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe 2019 novel coronavirus (SARS-CoV-2) is a new human coronavirus which is spreading with epidemic features in China and other Asian countries; cases have also been reported worldwide. This novel coronavirus disease (COVID-19) is associated with a respiratory illness that may lead to severe pneumonia and acute respiratory distress syndrome (ARDS). Although related to the severe acute respiratory syndrome (SARS) and the Middle East respiratory syndrome (MERS), COVID-19 shows some peculiar pathogenetic, epidemiological and clinical features which to date are not completely understood.

aimsTo provide a review of the differences in pathogenesis, epidemiology and clinical features of COVID-19, SARS and MERS. SOURCES: The most recent literature in the English language regarding COVID-19 has been reviewed, and extracted data have been compared with the current scientific evidence about SARS and MERS epidemics. CONTENT: COVID-19 seems not to be very different from SARS regarding its clinical features. However, it has a fatality rate of 2.3%, lower than that of SARS (9.5%) and much lower than that of MERS (34.4%). The possibility cannot be excluded that because of the less severe clinical picture of COVID-19 it can spread in the community more easily than MERS and SARS. The actual basic reproductive number (R IMPLICATIONS: There is still much more to know about COVID-19, especially as concerns mortality and its capacity to spread on a pandemic level. Nonetheless, all of the lessons we learned in the past from the SARS and MERS epidemics are the best cultural weapons with which to face this new global threat.

Indexed as

Basic Reproduction NumberBetacoronavirusCoronavirus InfectionsCOVID-19HumansPandemicsPhylogenyPneumonia, ViralSARS-CoV-2Severe Acute Respiratory SyndromeSevere acute respiratory syndrome-related coronavirusVirus AttachmentCoronavirusCOVID-19Emerging infectionsMERSSARS

Identifiers

PMID32234451
PMCPMC7176926
OpenAlexW3013008917

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.