Evidence map›Paper›PMID 32234291›Full record

ReviewRedox biology2020

Physical activity and exercise: Strategies to manage frailty.

Javier Angulo, Mariam El Assar, Alejandro Álvarez-Bustos, Leocadio Rodríguez-Mañas

3 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Redox biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 379 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
379citing papers in PubMed, 14 pooled it
30.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06465602 phase2unknown statusnot on this mapstarted 2024, after this paper: background citation

Nicotinamide Supplementation Improves Physical Performance in Older Adults at Risk of Falls: a Pilot Randomized Clinical Trial

TypeinterventionalSponsorUniversity of ChileRan2024 to 2025Enrolled60ConditionsFrailty, Fall, Frailty Syndrome, FallsArmsNicotinamide, Placebo
NCT07447453 narecruitingnot on this mapstarted 2025, after this paper: background citation

Computational Ecosystem With Motivational Support and Functional Assessment for an Autonomous Exercise Program Promoting Healthy Aging (MOTIVA)

TypeinterventionalSponsorHospital Universitario GetafeRan2025 to 2026Enrolled190ConditionsFrailty at Older AdultsArmsMOTIVA ecosystem
NCT07572851 enrolling by invitationnot on this mapstarted 2026, after this paper: background citation

Observational Study of Functional Changes and Fall Risk in Older Adults Participating in a Multicomponent Frailty and Falls Prevention Program in Primary Care

TypeobservationalSponsorUniversity of VigoRan2026 to 2026Enrolled56ConditionsFrail Elderly, Fall RiskArmsMulticomponent Exercise Program- 1 times per week., Multicomponent Exercise Program- 2 times per week.
3 · Its place in the literature

Who cites it

379 citing papers in PubMed, 14 syntheses or guidelines pooled it, 715 citations in OpenAlex.

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319 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Javier AnguloServicio de Histología-Investigación, Unidad de Investigación Traslacional en Cardiología (IRYCIS-UFV), Hospital Universitario Ramón y Cajal, Madrid, Spain; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain.
Mariam El AssarCentro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain; Fundación para la Investigación Biomédica del Hospital Universitario de Getafe, Getafe, Spain.
Alejandro Álvarez-BustosFundación para la Investigación Biomédica del Hospital Universitario de Getafe, Getafe, Spain.
Leocadio Rodríguez-MañasCentro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain; Servicio de Geriatría, Hospital Universitario de Getafe, Getafe, Spain. Electronic address: leocadio.rodriguez@salud.madrid.org.
Hospital Universitario de Getafe · ESCentro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable · ESInstituto Ramón y Cajal de Investigación Sanitaria · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Frailty, a consequence of the interaction of the aging process and certain chronic diseases, compromises functional outcomes in the elderly and substantially increases their risk for developing disabilities and other adverse outcomes. Frailty follows from the combination of several impaired physiological mechanisms affecting multiple organs and systems. And, though frailty and sarcopenia are related, they are two different conditions. Thus, strategies to preserve or improve functional status should consider systemic function in addition to muscle conditioning. Physical activity/exercise is considered one of the main strategies to counteract frailty-related physical impairment in the elderly. Exercise reduces age-related oxidative damage and chronic inflammation, increases autophagy, and improves mitochondrial function, myokine profile, insulin-like growth factor-1 (IGF-1) signaling pathway, and insulin sensitivity. Exercise interventions target resistance (strength and power), aerobic, balance, and flexibility work. Each type improves different aspects of physical functioning, though they could be combined according to need and prescribed as a multicomponent intervention. Therefore, exercise intervention programs should be prescribed based on an individual's physical functioning and adapted to the ensuing response.

Indexed as

FrailtySarcopeniaAdaptation, PhysiologicalAgedExerciseExercise TherapyFrail ElderlyHumansAgingExerciseFrailtyMulticomponent interventionOxidative stressPhysical activity

Identifiers

PMID32234291
PMCPMC7284931
OpenAlexW3011192505

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.