Evidence map›Paper›PMID 32234213›Full record

ArticleeLife2020

Calcium-stimulated disassembly of focal adhesions mediated by an ORP3/IQSec1 complex.

Ryan S D'Souza, Jun Y Lim, Alper Turgut, Kelly Servage, Junmei Zhang, Kim Orth, Nisha G Sosale, Matthew J Lazzara, Jeremy Allegood, James E Casanova

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
4.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 80 citations in OpenAlex.

  1. ARF GTPases Function at the Golgi.Sub-cellular biochemistry · 2026
    Review
  2. Article
  3. Review
  4. Phosphatidylinositol 4-phosphate; A minor lipid with multiple personalities.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2025
    Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Loss of ARF5 impairs recovery after lysosomal damage.Frontiers in molecular biosciences · 2025
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Ryan S D'SouzaDepartment of Cell Biology, University of Virginia Health System, Charlottesville, United States.
Jun Y LimDepartment of Cell Biology, University of Virginia Health System, Charlottesville, United States.
Alper TurgutDepartment of Cell Biology, University of Virginia Health System, Charlottesville, United States.
Kelly ServageDepartment of Molecular Biology, University of Texas Southwest Medical Center, Dallas, United States.ORCID 0000-0001-7183-2865
Junmei ZhangDepartment of Cell Biology, University of Virginia Health System, Charlottesville, United States.
Kim OrthDepartment of Molecular Biology, University of Texas Southwest Medical Center, Dallas, United States.ORCID 0000-0002-0678-7620
Nisha G SosaleDepartment of Chemical Engineering, University of Virginia, Charlottesville, United States.
Matthew J LazzaraDepartment of Chemical Engineering, University of Virginia, Charlottesville, United States.
Jeremy AllegoodDepartment of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, United States.
James E CasanovaDepartment of Cell Biology, University of Virginia Health System, Charlottesville, United States.ORCID 0000-0002-0858-2899
University of Virginia Health System · USHoward Hughes Medical Institute · USUniversity of Virginia · USVirginia Commonwealth University · US

Funding

Role of ARF5 and ER/plasma membrane contacts in the control of cell migrationR01GM127361 · NIGMS · UNIVERSITY OF VIRGINIA · PI CASANOVA, JAMES E. · 2019 to 2022
$1.4M
NIGMS NIH HHS R01 GM127361
6 · The paper itself

Abstract

Coordinated assembly and disassembly of integrin-mediated focal adhesions (FAs) is essential for cell migration. Many studies have shown that FA disassembly requires Ca

Indexed as

ADP-Ribosylation FactorsCalciumCell MembraneCells, CulturedFatty Acid-Binding ProteinsFocal AdhesionsGuanine Nucleotide Exchange FactorsHumansLipid MetabolismOxysterol Binding ProteinsPhosphatidylcholinesPhosphatidylinositolsADP-Ribosylation FactorsARF5 protein, humanCalciumFatty Acid-Binding ProteinsGuanine Nucleotide Exchange FactorsIQSEC1 protein, humanOSBPL3 protein, humanOxysterol Binding ProteinsPhosphatidylcholinesPhosphatidylinositolscell adhesioncell biologycell migrationGTPasehumanIQSec1lipid transferORP

Identifiers

PMID32234213
PMCPMC7159923
OpenAlexW3014507212

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.