ArticlePsychological medicine2021
Genetic liability to schizophrenia is associated with exposure to traumatic events in childhood.
Article in Psychological medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Genetic and environment influences on childhood victimization: a systematic review and meta-analysis.Molecular psychiatry · 2025Pooled it
- Childhood Maltreatment and Mental Health Problems: A Systematic Review and Meta-Analysis of Quasi-Experimental Studies.The American journal of psychiatry · 2023Pooled it
- Schizophrenia Polygenic Risk and Experiences of Childhood Adversity: A Systematic Review and Meta-analysis.Schizophrenia bulletin · 2022Pooled it
- Using Mendelian randomization analysis to better understand the relationship between mental health and substance use: a systematic review.Psychological medicine · 2021Pooled it
- Evidence-based atlas of risk and protective factors for psychotic disorders: an umbrella review to inform personalized prognosis and prevention.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026Article
- Investigating the impact of early adversity on perceived support from parents and friends in preadolescence: Do genetic predispositions and timing of exposure matter?JCPP advances · 2026Article
- Personality and mental health as mediators linking childhood maltreatment to intimate partner violence victimization: a Mendelian randomization-direction of causation twin study.The Lancet regional health. Europe · 2026Article
- The longitudinal association between adverse childhood experiences and persistence of psychotic-like experiences in young people: evidence from the ALSPAC birth cohort.Psychological medicine · 2026Article
- Association between the Korea-Polyenvironmental Risk Score and Clinical Outcomes in Schizophrenia Spectrum Disorders.Schizophrenia bulletin · 2026Article
- Autistic traits in childhood and post-traumatic stress disorder as young adults: a cohort study.Journal of child psychology and psychiatry, and allied disciplines · 2025Article
- The relationship between childhood maltreatment and trauma and psychosis is not moderated by parental mental health.BMC psychiatry · 2025Article
- Associations of polygenic risk score, environmental factors, and their interactions with the risk of schizophrenia spectrum disorders.Psychological medicine · 2025Article
- Genetic predisposition for negative affect predicts mental health burden during the COVID-19 pandemic.European archives of psychiatry and clinical neuroscience · 2025Article
- Childhood Adversity and Incident Psychotic Experiences in Early Adulthood: Cognitive and Psychopathological Mediators.Schizophrenia bulletin · 2024Article
- Childhood trauma and psychosis-Searching for causes and mechanisms.Schizophrenia research · 2023Article
- Genetic Decomposition of the Heritable Component of Reported Childhood Maltreatment.Biological psychiatry global open science · 2023Article
- A Prospective Cohort Study on the Intergenerational Transmission of Childhood Adversity and Subsequent Risk of Psychotic Experiences in Adolescence.Schizophrenia bulletin · 2023Article
- A genetically informed Registered Report on adverse childhood experiences and mental health.Nature human behaviour · 2023Article
- Schizophrenia polygenic risk is associated with child mental health problems through early childhood adversity: evidence for a gene-environment correlation.European child & adolescent psychiatry · 2022Article
- Profiles and factors associated with schizophrenia in eastern Ethiopia: A matched case-control study.Frontiers in psychiatry · 2022Article
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Abstract
backgroundThere is a wealth of literature on the observed association between childhood trauma and psychotic illness. However, the relationship between childhood trauma and psychosis is complex and could be explained, in part, by gene-environment correlation.
methodsThe association between schizophrenia polygenic scores (PGS) and experiencing childhood trauma was investigated using data from the Avon Longitudinal Study of Parents and Children (ALSPAC) and the Norwegian Mother, Father and Child Cohort Study (MoBa). Schizophrenia PGS were derived in each cohort for children, mothers, and fathers where genetic data were available. Measures of trauma exposure were derived based on data collected throughout childhood and adolescence (0-17 years; ALSPAC) and at age 8 years (MoBa).
resultsWithin ALSPAC, we found a positive association between schizophrenia PGS and exposure to trauma across childhood and adolescence; effect sizes were consistent for both child or maternal PGS. We found evidence of an association between the schizophrenia PGS and the majority of trauma subtypes investigated, with the exception of bullying. These results were comparable with those of MoBa. Within ALSPAC, genetic liability to a range of additional psychiatric traits was also associated with a greater trauma exposure.
conclusionsResults from two international birth cohorts indicate that genetic liability for a range of psychiatric traits is associated with experiencing childhood trauma. Genome-wide association study of psychiatric phenotypes may also reflect risk factors for these phenotypes. Our findings also suggest that youth at higher genetic risk might require greater resources/support to ensure they grow-up in a healthy environment.
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