ArticleBMC medicine2020
Risk of long-term renal disease in women with a history of preterm delivery: a population-based cohort study.
Article in BMC medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Association between maternal pregnancy complications and long-term depressive and anxiety disorders: evidence from the UK millennium cohort study.Social psychiatry and psychiatric epidemiology · 2026Article
- Gestational Age at Delivery Is an Independent Predictor of Neonatal Outcome for Maternal HELLP Syndrome.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Article
- Association between preterm delivery and the risk of maternal renal disease: A systematic review and meta‑analysis.Experimental and therapeutic medicine · 2024Article
- Adverse pregnancy outcomes and long-term risk of chronic kidney disease in women: national cohort and co-sibling study.American journal of obstetrics and gynecology · 2024Article
- Pregnancy Complications and Long-Term Mortality in a Diverse Cohort.Circulation · 2023Article
- Does gestational diabetes increase the risk of maternal kidney disease? A Swedish national cohort study.PloS one · 2022Article
- Risk of chronic kidney disease in women with a history of preterm delivery: Tehran Lipid and Glucose Study.Journal of nephrology · 2021Article
- An observational claims data analysis on the risk of maternal chronic kidney disease after preterm delivery and preeclampsia.Scientific reports · 2021Article
- A History of Preterm Delivery Is Associated with Aberrant Postpartal MicroRNA Expression Profiles in Mothers with an Absence of Other Pregnancy-Related Complications.International journal of molecular sciences · 2021Article
- Editorial: Adverse Pregnancy Outcomes-A Missed Opportunity to Prevent Chronic Disease?International journal of public healthArticle
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundPreterm delivery is an independent risk factor for maternal cardiovascular disease. Little is known about the association between preterm delivery and maternal renal function. This study aimed to examine whether women who experience preterm delivery are at increased risk of subsequent chronic kidney disease (CKD) and end-stage kidney disease (ESKD).
methodsUsing data from the Swedish Medical Birth Register, singleton live births from 1973 to 2012 were identified and linked to data from the Swedish Renal Register and National Patient Register (up to 2013). Gestational age at delivery was the main exposure and treated as a time-dependent variable. Primary outcomes were maternal CKD or ESKD. Cox proportional hazard regression models were used for analysis.
resultsThe dataset included 1,943,716 women who had 3,760,429 singleton live births. The median follow-up was 20.6 (interquartile range 9.9-30.0) years. Overall, 162,918 women (8.4%) delivered at least 1 preterm infant (< 37 weeks). Women who had any preterm delivery (< 37 weeks) were at increased risk of CKD (adjusted hazard ratio (aHR) 1.39, 95% CI 1.32-1.45) and ESKD (aHR 2.22, 95% CI 1.90-2.58) compared with women who only delivered at term (≥ 37 weeks). Women who delivered an extremely preterm infant (< 28 weeks) were at increased risk of CKD (aHR 1.84, 95% CI 1.52-2.22) and ESKD (aHR 3.61, 95% CI 2.03-6.39). The highest risk of CKD and ESKD was in women who experienced preterm delivery + preeclampsia (vs. non-preeclamptic term deliveries, for CKD, aHR 2.81, 95% CI 2.46-3.20; for ESKD, aHR 6.70, 95% CI 4.70-9.56). However, spontaneous preterm delivery was also associated with increased risk of CKD (aHR 1.32, 95% CI 1.25-1.39) and ESKD (aHR 1.99, 95% CI 1.67-2.38) independent of preeclampsia or small for gestational age (SGA).
conclusionsWomen with history of preterm delivery are at increased risk of CKD and ESKD. The risk is higher among women who had very preterm or extremely preterm deliveries, or whose preterm delivery was medically indicated. Women who experience spontaneous preterm delivery are at increased risk of long-term renal disease independent of preeclampsia or SGA. Preterm delivery may act as a risk marker for adverse maternal renal outcomes.
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