Evidence map›Paper›PMID 32233911›Full record

ArticleJournal of neurophysiology2020

Phrenic motor neuron loss in an animal model of early onset hypertonia.

Joline E Brandenburg, Matthew J Fogarty, Alyssa D Brown, Gary C Sieck

Open access · greenAbstract read
In one paragraph

Article in Journal of neurophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Modeling cerebral palsy in animals.Developmental medicine and child neurology · 2026
    Review
  4. Postnatal survival of phrenic motor neurons is promoted by BDNF/TrkB.FL signaling.Journal of applied physiology (Bethesda, Md. : 1985) · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Size-dependent differences in mitochondrial volume density in phrenic motor neurons.Journal of applied physiology (Bethesda, Md. : 1985) · 2023
    Article
  9. Inhibitory Synaptic Influences on Developmental Motor Disorders.International journal of molecular sciences · 2023
    Review
  10. Is baclofen the least worst option for spasticity management in children?Journal of pediatric rehabilitation medicine · 2023
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Diaphragm muscle function in a mouse model of early-onset spasticity.Journal of applied physiology (Bethesda, Md. : 1985) · 2022
    Article
  16. Article
  17. Article
  18. Article
  19. Growth and survival characteristics ofAnimal models and experimental medicine · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Joline E BrandenburgDepartment of Physical Medicine and Rehabilitation, Mayo Clinic College of Medicine, Rochester, Minnesota.ORCID 0000-0002-7932-9225
Matthew J FogartyDepartment of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota.
Alyssa D BrownDepartment of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota.
Gary C SieckDepartment of Physical Medicine and Rehabilitation, Mayo Clinic College of Medicine, Rochester, Minnesota.
Mayo Clinic · US

Funding

Respiratory Control in Old AgeR01AG044615 · NIA · MAYO CLINIC ROCHESTER · PI MANTILLA, CARLOS B, SIECK, GARY C. · 2013 to 2025
$6.9M
Enhancing Respiratory Motor Function after Spinal Cord InjuryR01HL146114 · NHLBI · MAYO CLINIC ROCHESTER · PI Carlos B Mantilla, Gary C. Sieck · 2019 to 2026
$5.4M
Recovery of Respiratory Function After Spinal Cord InjuryR01HL096750 · NHLBI · MAYO CLINIC ROCHESTER · PI MANTILLA, CARLOS B, SIECK, GARY C. · 2010 to 2017
$4.9M
Interdisciplinary Training in Lung Physiology and Biomedical EngineeringT32HL105355 · NHLBI · MAYO CLINIC ROCHESTER · PI PRAKASH, Y. S., SIECK, GARY C. · 2012 to 2021
$3.9M
PLASTICITY IN DIAPHRAGM NEUROMOTOR CONTROLR01HL037680 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SIECK, GARY C. · 1987 to 2007
$2.6M
NHLBI NIH HHS R01 HL037680NHLBI NIH HHS R01 HL096750NHLBI NIH HHS R01 HL146114NHLBI NIH HHS T32 HL105355NIA NIH HHS R01 AG044615
6 · The paper itself

Abstract

Phrenic motor neuron (PhMN) development in early onset hypertonia is poorly understood. Respiratory disorders are one of the leading causes of morbidity and mortality in individuals with early onset hypertonia, such as cerebral palsy (CP), but they are largely overshadowed by a focus on physical function in this condition. Furthermore, while the brain is the focus of CP research, motor neurons, via the motor unit and neurotransmitter signaling, are the targets in clinical interventions for hypertonia. Furthermore, critical periods of spinal cord and motor unit development also coincide with the timing that the supposed brain injury occurs in CP. Using an animal model of early-onset spasticity (

Indexed as

DiaphragmMotor NeuronsMuscle HypertoniaPhrenic NerveReceptors, GlycineSpinal CordAnimalsDisease Models, AnimalFemaleMaleMiceMice, KnockoutMuscle SpasticityRespiration DisordersGlrb protein, mouseReceptors, Glycinediaphragmglycine receptorspasticityspinal cord

Identifiers

PMID32233911
PMCPMC7444911
OpenAlexW3014174011

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.