ArticleAnnals of the Royal College of Surgeons of England2020
Papillary thyroid microcarcinoma presenting as a metastasis to the brain.
Article in Annals of the Royal College of Surgeons of England, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Nodal metastases in papillary thyroid microcarcinoma: prevalence and risk factors in 311 patients.Virchows Archiv : an international journal of pathology · 2026Article
- Brain metastasis mimicking a cavernous angioma as initial presentation of papillary thyroid carcinoma.Endocrinology, diabetes & metabolism case reports · 2024Article
- Subcentimetric papillary thyroid carcinoma with extensive lymph node and brain metastasis: case report and review of literature.Endocrinology, diabetes & metabolism case reports · 2023Article
- The Significance of Unsampled Microscopic Thyroid Carcinomas in Multinodular Goiter.Endocrine pathology · 2023Article
- Risk factors of papillary thyroid microcarcinoma that predispose patients to local recurrence.PloS one · 2020Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The brain is a particularly rare site of metastasis from papillary microcarcinoma, with only few cases described in the literature. We present a case of 59-year-old man who presented with seizures and dysphasia due to left frontal lobe cystic mass, which was excised and turned out on histopathology to be of thyroid origin. Total thyroidectomy was performed and histology showed multifocal papillary microcarcinoma with the largest focus of 3mm with no other adverse features. The patient had ablative radioactive iodine postoperatively, with subsequent exit scan showing no uptake in the brain. Follow-up brain magnetic resonance imaging showed continuous regression of the surgical cavity. Although rare, such cases should be aggressively treated and followed up over the long term, because of reported associated high mortality.
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