Observational studyJournal of the American Heart Association2020
Early-Life Famine Exposure and Risk of Cardiovascular Diseases in Later Life: Findings From the REACTION Study.
Open access · goldAbstract readComparative StudyMulticenter StudyObservational Study
In one paragraph
Observational study in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33citing papers in PubMed
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Who cites it
33 citing papers in PubMed, 59 citations in OpenAlex.
- Challenges and knowledge gaps in sex differences in cardio-kidney-metabolic syndrome across the lifespan.Biology of sex differences · 2026Review
- Childhood famine exposure and the risk of gastrointestinal diseases in old individuals: a retrospective cohort analysis using the CHARLS database.BMC public health · 2026Article
- Review
- Early Life Exposure to the Great Chinese Famine and Cardiometabolic Outcomes.JAMA network open · 2025Article
- Age-period-cohort analysis of cardiovascular disease trends in middle-aged and older adults: cross-country comparison across HRS, ELSA, SHARE, and CHARLS.Journal of global health · 2025Article
- The association of famine exposure with healthy lifestyles at different life stages in rural older adults in China.Frontiers in public health · 2025Article
- Fetal exposure to famine increases the risk of cardiovascular disease in adulthood: findings from a population-based screening study.Frontiers in cardiovascular medicine · 2025Article
- Factors associated with metabolic syndrome among adult residents in Dalian: a nested case-control study.Frontiers in endocrinology · 2025Article
- Clinical characteristics and complication risks in data-driven clusters among Chinese community diabetes populations.Journal of diabetes · 2024Article
- Early-life tobacco smoke exposure and stroke risk: a prospective study of 341,783 and 352,737 UK Biobank participants.BMC public health · 2024Article
- Early-life famine exposure, adulthood obesity patterns, and risk of low-energy fracture.Frontiers of medicine · 2024Article
- Exposure to Chinese famine and the risk of hyperuricemia in later life: a population-based cross-sectional study.Frontiers in nutrition · 2024Article
- Association between triglyceride glucose index and breast cancer in 142,184 Chinese adults: findings from the REACTION study.Frontiers in endocrinology · 2024Article
- Exposures to great Chinese Famine during embryo, foetal or infant stages link differently with risks of cardiovascular diseases in late middle age.Journal of nutritional science · 2024Article
- Association of early life adversity with cardiovascular disease and its potential mechanisms: a narrative review.Frontiers in public health · 2024Review
- Article
- Relationships between Age at Menarche and Risk of Cardiovascular Disease Mortality among Japanese Women: The Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC) Study.Journal of atherosclerosis and thrombosis · 2023Article
- Long-Term Impact of the Great Chinese Famine on the Risks of Specific Arrhythmias and Severe Hypertension in the Offspring at an Early Stage of Aging.Journal of personalized medicine · 2023Article
- Effect of night shift work on metabolic syndrome in adults who suffered from earthquake stress in early life.Frontiers in public health · 2023Article
- Editorial: Diet and nutrition for non-communicable diseases in low and middle-income countries.Frontiers in nutrition · 2023Article
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Authors and funding
44 authors at 20 institutions in 2 countries.
Rui DuState Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui-Jin Hospital Shanghai Jiao-Tong University School of Medicine Shanghai China.
Ruizhi ZhengState Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui-Jin Hospital Shanghai Jiao-Tong University School of Medicine Shanghai China.
Yu XuState Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui-Jin Hospital Shanghai Jiao-Tong University School of Medicine Shanghai China.
Yuanyue ZhuState Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui-Jin Hospital Shanghai Jiao-Tong University School of Medicine Shanghai China.
Xuefeng YuTongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China.
Mian LiState Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui-Jin Hospital Shanghai Jiao-Tong University School of Medicine Shanghai China.
Xulei TangThe First Hospital of Lanzhou University Lanzhou China.
Ruying HuZhejiang Provincial Center for Disease Control and Prevention Hangzhou China.
Qing SuXinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine Shanghai China.
Tiange WangState Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui-Jin Hospital Shanghai Jiao-Tong University School of Medicine Shanghai China.
Zhiyun ZhaoState Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui-Jin Hospital Shanghai Jiao-Tong University School of Medicine Shanghai China.
Min XuState Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui-Jin Hospital Shanghai Jiao-Tong University School of Medicine Shanghai China.
Yuhong ChenState Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui-Jin Hospital Shanghai Jiao-Tong University School of Medicine Shanghai China.
Lixin ShiAffiliated Hospital of Guiyang Medical College Guiyang China.
Qin WanThe Affiliated Hospital of Luzhou Medical College Luzhou China.
Gang ChenFujian Provincial Hospital Fujian Medical University Fuzhou China.
Meng DaiState Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui-Jin Hospital Shanghai Jiao-Tong University School of Medicine Shanghai China.
Di ZhangState Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui-Jin Hospital Shanghai Jiao-Tong University School of Medicine Shanghai China.
Zhengnan GaoDalian Municipal Central Hospital Dalian China.
Guixia WangThe First Hospital of Jilin University Changchun China.
Feixia ShenThe First Affiliated Hospital of Wenzhou Medical University Wenzhou China.
Zuojie LuoThe First Affiliated Hospital of Guangxi Medical University Nanning China.
Yingfen QinThe First Affiliated Hospital of Guangxi Medical University Nanning China.
Li ChenQilu Hospital of Shandong University Jinan China.
Yanan HuoJiangxi Provincial People's Hospital Affiliated to Nanchang University Nanchang China.
Qiang LiThe Second Affiliated Hospital of Harbin Medical University Harbin China.
Zhen YeZhejiang Provincial Center for Disease Control and Prevention Hangzhou China.
Yinfei ZhangCentral Hospital of Shanghai Jiading District Shanghai China.
Chao LiuJiangsu Province Hospital on Integration of Chinese and Western Medicine Nanjing China.
Youmin WangThe First Affiliated Hospital of Anhui Medical University Hefei China.
Shengli WuKaramay Municipal People's Hospital Xinjiang China.
Tao YangThe First Affiliated Hospital of Nanjing Medical University Nanjing China.
Huacong DengThe First Affiliated Hospital of Chongqing Medical University Chongqing China.
Lulu ChenUnion Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China.
Jiajun ZhaoShandong Provincial Hospital affiliated to Shandong University Jinan China.
Yiming MuChinese People's Liberation Army General Hospital Beijing China.
Donghui LiDepartment of Gastrointestinal Medical Oncology The University of Texas MD Anderson Cancer Center Houston TX.
Guijun QinThe First Affiliated Hospital of Zhengzhou University Zhengzhou China.
Weiqing WangState Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui-Jin Hospital Shanghai Jiao-Tong University School of Medicine Shanghai China.
Guang NingState Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui-Jin Hospital Shanghai Jiao-Tong University School of Medicine Shanghai China.
Li YanSun Yat-sen Memorial Hospital Sun Yat-sen University Guangzhou China.
Yufang BiState Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui-Jin Hospital Shanghai Jiao-Tong University School of Medicine Shanghai China.
Jieli LuState Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui-Jin Hospital Shanghai Jiao-Tong University School of Medicine Shanghai China.
REACTION Study Group ‡
Shanghai Jiao Tong University · CNGuangxi Medical University · CNQilu Hospital of Shandong University · CNZhejiang Center for Disease Control and Prevention · CNAnhui Medical University · CNChinese People's Liberation Army · CNDalian Municipal Central Hospital · CNFirst Affiliated Hospital of Chongqing Medical University · CNFirst Affiliated Hospital of Sichuan Medical University · CNFirst Affiliated Hospital of Zhengzhou University · CNFujian Medical University · CNHarbin Medical University · CNHuazhong University of Science and Technology · CNJiading District Central Hospital · CNJiangsu Province Hospital · CNJiangxi Provincial People's Hospital · CNJilin University · CNKaramay Central Hospital · CNLanzhou University · CNNanjing Medical University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Previous studies reported that early-life exposure to undernutrition is associated with the risk of diabetes mellitus and metabolic syndrome in adulthood, but the association with risk of cardiovascular disease (CVD) later in life remains unclear. The current study aimed to investigate whether exposure to Chinese famine in early life is associated with risk of CVD. Methods and Results We used data from REACTION (Risk Evaluation of Cancers in Chinese Diabetic Individuals: A Longitudinal Study), which recruited a total of 259 657 community-dwelling adults aged 40 years or older from 25 centers across mainland China between 2011 and 2012. Compared with the nonexposed participants, those who had been exposed to famine in early life had a significantly increased risk of total CVD, myocardial infarction, stroke, and coronary heart disease. In the multivariable-adjusted logistic regression model, the odds ratios (95% CI) for total CVD, myocardial infarction, stroke, and coronary heart disease in fetal famine exposure were 1.35 (1.20-1.52), 1.59 (1.08-2.35), 1.40 (1.11-1.78), and 1.44 (1.26-1.65), respectively; those odds ratios in childhood famine exposure were 1.59 (1.40-1.81), 2.20 (1.52-3.20), 1.82 (1.45-2.28), and 1.80 (1.56-2.09), respectively; and those in adolescent famine exposure were 1.52 (1.27-1.81), 2.07 (1.28-3.35), 1.92 (1.42-2.58), and 1.83 (1.50-2.24), respectively. The main finding of our study is that, compared with those who lived in the less severely affected famine area, individuals in the severely affected famine area had significantly increased risk of total CVD in all 3 exposed groups. Conclusions Early-life exposure to undernutrition is associated with significantly increased risk of CVD in later life, especially among those who were in the severely affected famine area.
Indexed as
Adverse Childhood ExperiencesFamineAdolescentAdultAgedAge FactorsCardiovascular DiseasesChildChild Nutrition DisordersChild, PreschoolChinaCross-Sectional StudiesFemaleHeart Disease Risk FactorsHumansInfantassociationcardiovascular diseasesearly‐life exposurefamine
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