Evidence map›Paper›PMID 32233138›Full record

ArticleJournal of veterinary science2020

Pharmacokinetic profiles of levofloxacin after intravenous, intramuscular and subcutaneous administration to rabbits (

Andrejs Sitovs, Laura Voiko, Dmitrijs Kustovs, Liga Kovalcuka, Dace Bandere, Santa Purvina, Mario Giorgi

Open access · goldAbstract read
In one paragraph

Article in Journal of veterinary science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Comparative effects of systemic administration of levofloxacin and cephalexin on fracture healing in rats.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Andrejs SitovsDepartment of Pharmacology, Riga Stradins University, Riga, LV-1007, Latvia. andrejs.sitovs@rsu.lv.ORCID https://orcid.org/0000-0002-9529-8799
Laura VoikoClinical Institute, Faculty of Veterinary Medicine, University of Life Sciences and Technologies, Jelgava, LV-3001, Latvia.ORCID https://orcid.org/0000-0002-4552-6167
Dmitrijs KustovsDepartment of Pharmacology, Riga Stradins University, Riga, LV-1007, Latvia.ORCID https://orcid.org/0000-0001-8788-0204
Liga KovalcukaClinical Institute, Faculty of Veterinary Medicine, University of Life Sciences and Technologies, Jelgava, LV-3001, Latvia.ORCID https://orcid.org/0000-0002-2524-7427
Dace BandereDepartment of Pharmaceutical Chemistry, Riga Stradins University, Riga, LV-1007, Latvia.ORCID https://orcid.org/0000-0001-9144-8799
Santa PurvinaDepartment of Pharmacology, Riga Stradins University, Riga, LV-1007, Latvia.ORCID https://orcid.org/0000-0002-4934-3106
Mario GiorgiDepartment of Veterinary Sciences, University of Pisa, Pisa 56126, Italy.ORCID https://orcid.org/0000-0003-3657-4703
Riga Stradiņš University · LVLatvia University of Life Sciences and Technologies · LVUniversity of Pisa · IT

Funding

Riga Stradins University
6 · The paper itself

Abstract

Levofloxacin pharmacokinetic profiles were evaluated in 6 healthy female rabbits after intravenous (I/V), intramuscular (I/M), or subcutaneous (S/C) administration routes at a single dose of 5 mg/kg in a 3 × 3 cross-over study. Plasma levofloxacin concentrations were detected using a validated Ultra Performance Liquid Chromatography method with a fluorescence detector. Levofloxacin was quantifiable up to 10 h post-drug administration. Mean AUC

Indexed as

AnimalsAnti-Infective AgentsCross-Over StudiesInjections, IntramuscularInjections, IntravenousInjections, SubcutaneousLevofloxacinMicrobial Sensitivity TestsRabbitsAnti-Infective AgentsLevofloxacinLevofloxacinosmolar concentrationpharmacokineticsrabbitstears

Identifiers

PMID32233138
PMCPMC7113567
OpenAlexW3009119877

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.