Evidence map›Paper›PMID 32233099›Full record

ArticleAnnals of the New York Academy of Sciences2020

Alleviation of methyl isocyanate-induced airway obstruction and mortality by tissue plasminogen activator.

Heidi J Nick, Jacqueline S Rioux, Livia A Veress, Preston E Bratcher, Leslie A Bloomquist, Poojya Anantharam, Claire R Croutch, Richard S Tuttle, Eric Peters, William Sosna and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of the New York Academy of Sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Mesna Improves Outcomes of Sulfur Mustard Inhalation Toxicity in an Acute Rat Model.The Journal of pharmacology and experimental therapeutics · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Heidi J NickDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Jacqueline S RiouxDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Livia A VeressDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Preston E BratcherDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Leslie A BloomquistDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Poojya AnantharamMRIGlobal, Kansas City, Missouri.
Claire R CroutchMRIGlobal, Kansas City, Missouri.
Richard S TuttleMRIGlobal, Kansas City, Missouri.
Eric PetersMRIGlobal, Kansas City, Missouri.
William SosnaMRIGlobal, Kansas City, Missouri.
Carl W WhiteDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
MRIGlobal · USUniversity of Colorado Anschutz Medical Campus · USNational Jewish Health · US

Funding

Photonics Monitoring and Modeling CoreU54ES027698 · NIEHS · UNIVERSITY OF COLORADO DENVER · PI WHITE, CARL W · 2016 to 2021
$16.7M
NIEHS NIH HHS U54 ES027698
6 · The paper itself

Abstract

Methyl isocyanate (MIC, "Bhopal agent") is a highly reactive, toxic industrial chemical. Inhalation of high levels (500-1000 ppm) of MIC vapor is almost uniformly fatal. No therapeutic interventions other than supportive care have been described that can delay the onset of illness or death due to MIC. Recently, we found that inhalation of MIC caused the appearance of activated tissue factor in circulation with subsequent activation of the coagulation cascade. Herein, we report that MIC exposure (500 ppm for 30 min, nose-only) caused deposition of fibrin-rich casts in the conducting airways resulting in respiratory failure and death within 24 h in a rat model (LC

Indexed as

Airway ObstructionAnimalsDisease Models, AnimalIsocyanatesMaleRatsRats, Sprague-DawleyTissue Plasminogen ActivatorIsocyanatesmethyl isocyanateTissue Plasminogen Activatorairway obstructionBhopal agentfibrinmethyl isocyanate (MIC)tissue plasminogen activator (tPA)

Identifiers

PMID32233099
PMCPMC7529679
OpenAlexW3012960209

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.