ArticleJournal of clinical laboratory analysis2020
Role of platelet infiltration as independent prognostic marker for gastric adenocarcinomas.
Article in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- The role of platelets in cancer: from their influence on tumor progression to their potential use in liquid biopsy.Biomarker research · 2025Review
- Article
- Association between Platelet Count and In-Hospital Mortality in Critical Patients with Multiple Myeloma: A Cohort Study.PloS one · 2025Article
- Platelets as a prognostic factor for patients with adenocarcinoma of the gastroesophageal junction.Langenbeck's archives of surgery · 2023Article
- Clinical Significance of Fibrinogen and Platelet to Pre-Albumin Ratio in Predicting the Prognosis of Advanced Gastric Cancer.Journal of inflammation research · 2023Article
- Screening and validation of platelet activation-related lncRNAs as potential biomarkers for prognosis and immunotherapy in gastric cancer patients.Frontiers in genetics · 2022Article
- Role of platelet infiltration as independent prognostic marker for gastric adenocarcinomas.Journal of clinical laboratory analysis · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundIn recent years, the relationship between malignant tumors and platelets has been paid more attention. The increase of platelets is an independent risk factor for the poor prognosis of some malignant tumors.
methodsThis study retrospectively analyzed the clinical and pathological data of 114 patients with initial gastric cancer from August 2005 to August 2018 in Shandong Provincial Hospital. Single-factor and multifactor survival analysis were used to evaluate the effect of platelet elevation on postoperative survival. The gastric cancer tissues of the Jinan Central Hospital and its matched paracancerous tissues were collected. The expression of platelets in tissues was detected by immunofluorescence technique. Different numbers of platelets were co-cultured with MKN-45 cells, CCK-8 assay and transwell assay were performed, and the expression of epithelial-mesenchymal transition-related proteins was detected.
resultsPlatelet count was independent factors affecting prognosis. The stratified analysis showed that there was a statistically significant difference in the 5-year survival rate between the platelet-increase group and the normal platelet group in the TNM stages I-II. The expression of platelets in gastric cancer tissues was higher than that in adjacent tissues. The results of CCK-8 and transwell showed that platelets significantly enhanced the proliferation and metastasis capability of MKN-45 cells in a concentration-dependent manner. After co-culture, the expression level of E-cadherin protein in MKN-45 cells decreased, and the protein expression levels of N-cadherin, vimentin, and VEGFA increased.
conclusionPlatelet elevation is closely related to the occurrence, development, and metastasis of gastric cancer, and platelet count can be used as a prognostic indicator for malignant tumors.
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