Evidence map›Paper›PMID 32232979›Full record

ArticleJournal of medical virology2020

Analysis of heart injury laboratory parameters in 273 COVID-19 patients in one hospital in Wuhan, China.

Huan Han, Linlin Xie, Rui Liu, Jie Yang, Fang Liu, Kailang Wu, Lang Chen, Wei Hou, Yong Feng, Chengliang Zhu

Abstract read
In one paragraph

Article in Journal of medical virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers, 22 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
146citing papers in PubMed, 22 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

146 citing papers in PubMed, 22 syntheses or guidelines pooled it.

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  8. Meta-analysis of cardiac markers for predictive factors on severity and mortality of COVID-19.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021
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86 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Huan HanDepartment of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Linlin XieDepartment of Medical Microbiology, State Key Laboratory of Virology, School of Basic Medical Sciences, Wuhan, Hubei, China.
Rui LiuDepartment of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Jie YangDepartment of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Fang LiuDepartment of Virology, State Key Laboratory of Virology, College of Life Sciences, Wuhan, Hubei, China.
Kailang WuDepartment of Virology, State Key Laboratory of Virology, College of Life Sciences, Wuhan, Hubei, China.
Lang ChenDepartment of Medical Microbiology, State Key Laboratory of Virology, School of Basic Medical Sciences, Wuhan, Hubei, China.
Wei HouDepartment of Medical Microbiology, State Key Laboratory of Virology, School of Basic Medical Sciences, Wuhan, Hubei, China.
Yong FengDepartment of Medical Microbiology, State Key Laboratory of Virology, School of Basic Medical Sciences, Wuhan, Hubei, China.ORCID 0000-0003-1590-0186
Chengliang ZhuDepartment of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.

Funding

National Natural Science Foundation of China 81471940
6 · The paper itself

Abstract

An outbreak of severe acute respiratory syndrome novel coronavirus (SARS-CoV-2) epidemic spreads rapidly worldwide. SARS-CoV-2 infection caused mildly to seriously and fatally respiratory, enteric, cardiovascular, and neurological diseases. In this study, we detected and analyzed the main laboratory indicators related to heart injury, creatine kinase isoenzyme-MB (CK-MB), myohemoglobin (MYO), cardiac troponin I (ultra-TnI), and N-terminal pro-brain natriuretic peptide (NT-proBNP), in 273 patients with COVID-19 and investigated the correlation between heart injury and severity of the disease. It was found that higher concentration in venous blood of CK-MB, MYO, ultra-TnI, and NT-proBNP were associated with the severity and case fatality rate of COVID-19. Careful monitoring of the myocardiac enzyme profiles is of great importance in reducing the complications and mortality in patients with COVID-19.

Indexed as

AdultAgedBetacoronavirusBiomarkersChinaCoronavirus InfectionsCOVID-19Creatine Kinase, MB FormFemaleHeart InjuriesHospitalsHumansMaleMiddle AgedMyoglobinNatriuretic Peptide, BrainBiomarkersCreatine Kinase, MB FormMyoglobinNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)Troponin ICOVID-19disease severityheart injurylaboratory indicators

Identifiers

PMID32232979
PMCPMC7228305

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.