ArticleAnnals of biomedical engineering2020
A Valveless Pulsatile Pump for Heart Failure with Preserved Ejection Fraction: Hemo- and Fluid Dynamic Feasibility.
Article in Annals of biomedical engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Relationship between cardio-ankle vascular index and stagnation zone volume, measured using 4D flow magnetic resonance imaging, in patients with thoracic aortic atherosclerosis.The international journal of cardiovascular imaging · 2026Article
- Pre-Clinical Models of Heart Failure with Preserved Ejection Fraction: Advancing Knowledge for Device Based Therapies.Annals of biomedical engineering · 2025Review
- Use of in silico research in the development of abdominal and thoracic surgical devices: a systematic review.BMJ innovations · 2025Article
- A numerical study of a left ventricular expander for heart failure with preserved ejection fraction.Royal Society open science · 2023Article
- Isovolumetric Contraction as a Marker of Ventricular Performance in Patients with Afterload Mismatch.Diagnostics (Basel, Switzerland) · 2023Article
- Left atrial assist device for heart failure with preserved ejection fraction: initial results with torque control mode in diastolic heart failure model.Heart failure reviews · 2023Review
- Can mechanical circulatory support be an effective treatment for HFpEF patients?Heart failure reviews · 2023Review
- Soft robotic patient-specific hydrodynamic model of aortic stenosis and ventricular remodeling.Science robotics · 2023Article
- New Opportunities in Heart Failure with Preserved Ejection Fraction: From Bench to Bedside… and Back.Biomedicines · 2022Review
- Comparison of device-based therapy options for heart failure with preserved ejection fraction: a simulation study.Scientific reports · 2022Article
- Large animal models of heart failure with preserved ejection fraction.Heart failure reviews · 2022Review
- Framework for patient-specific simulation of hemodynamics in heart failure with counterpulsation support.Frontiers in cardiovascular medicine · 2022Article
- A Multi-Domain Simulation Study of a Pulsatile-Flow Pump Device for Heart Failure With Preserved Ejection Fraction.Frontiers in physiology · 2022Article
- Material property alterations for phenotypes of heart failure with preserved ejection fraction: A numerical study of subject-specific porcine models.Frontiers in bioengineering and biotechnology · 2022Article
- Device-based treatment options for heart failure with preserved ejection fraction.Heart failure reviews · 2021Review
- Device-Based Solutions to Improve Cardiac Physiology and Hemodynamics in Heart Failure With Preserved Ejection Fraction.JACC. Basic to translational scienceReview
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Treatment of heart failure with preserved ejection fraction (HFpEF) remains a major unmet medical need. An implantable valveless pulsatile pump with a single cannula-the CoPulse pump-may provide beneficial hemodynamic support for select HFpEF patients when connected to the failing ventricle. We aimed to demonstrate hemodynamic efficacy and hemocompatible design feasibility for this novel assist device. The hemodynamic effect of the pump was investigated with an in vitro circulatory mock loop and an ex vivo isolated porcine heart model. The hydraulic design was optimized using computational fluid dynamics (CFD), and validated by 4D-flow magnetic resonance imaging (MRI). The pump reduced left atrial pressure (> 27%) and increased cardiac output (> 14%) in vitro. Ex vivo experiments revealed elevated total stroke volume at increased end-systolic volume during pump support. Asymmetric cannula positioning indicated superior washout, decreased stagnation (8.06 mm
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